G2Cdb::Allele report

Mutation type
D

Altered genes (1)

Gene Symbol Species Description
G00000031 HRAS Homo sapiens v-Ha-ras Harvey rat sarcoma viral oncogene homolog

Diseases (1)

Disease Description Nervous effect
D00000138 Multiple endocrine neoplasia type I N

Literature (1)

Pubmed - human_disease

  • Loss of the same alleles of HRAS1 and D11S151 in two independent pancreatic cancers from a patient with multiple endocrine neoplasia type 1.

    Yoshimoto K, Iizuka M, Iwahana H, Yamasaki R, Saito H, Saito S and Sekiya T

    Oncogene Division, National Cancer Center Research Institute, Tokyo, Japan.

    The DNAs from two independent pancreatic cancers (tumors 1 and 2) in a patient with multiple endocrine neoplasia type 1 were analyzed. No amplification or gross rearrangement of 19 protooncogenes was observed. However, Southern blot analysis using polymorphic DNA probes revealed loss of heterozygosity at loci on chromosome 11p in both tumors. In tumor 1, an extensive region including the HRAS1, PTH, CALCA, and D11S151 loci was deleted, while in tumor 2 loss of heterozygosity was limited at the HRAS1 and D11S151 loci. Because loss of heterozygosity at other chromosomal loci in the two tumors was quite rare, loss of genes on 11p might be nonrandom. It is noteworthy that the same allele at the HRAS1 locus and also the same allele at the D11S151 locus were lost in the two independent tumors. These results suggest that loss of genes at the HRAS1 and/or D11S151 loci plays an important role unmasking the remaining sequences probably having a recessive mutation.

    Cancer research 1989;49;10;2716-21

© G2C 2014. The Genes to Cognition Programme received funding from The Wellcome Trust and the EU FP7 Framework Programmes:
EUROSPIN (FP7-HEALTH-241498), SynSys (FP7-HEALTH-242167) and GENCODYS (FP7-HEALTH-241995).

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