Publications with associated data resources

Full list of G2C puplications

  • De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.

    Kirov G, Pocklington AJ, Holmans P, Ivanov D, Ikeda M, Ruderfer D, Moran J, Chambert K, Toncheva D, Georgieva L, Grozeva D, Fjodorova M, Wollerton R, Rees E, Nikolov I, van de Lagemaat LN, Bayés A, Fernandez E, Olason PI, Böttcher Y, Komiyama NH, Collins MO, Choudhary J, Stefansson K, Stefansson H, Grant SG, Purcell S, Sklar P, O'Donovan MC and Owen MJ

    Molecular psychiatry 2012;17;2;142-53

  • Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases.

    Van Campenhout CA, Eitelhuber A, Gloeckner CJ, Giallonardo P, Gegg M, Oller H, Grant SG, Krappmann D, Ueffing M and Lickert H

    Developmental cell 2011;21;3;479-91

  • A novel role for PSD-95 in mediating ethanol intoxication, drinking and place preference.

    Camp MC, Feyder M, Ihne J, Palachick B, Hurd B, Karlsson RM, Noronha B, Chen YC, Coba MP, Grant SG and Holmes A

    Addiction biology 2011;16;3;428-39

  • Knockdown of mental disorder susceptibility genes disrupts neuronal network physiology in vitro.

    MacLaren EJ, Charlesworth P, Coba MP and Grant SG

    Molecular and cellular neurosciences 2011;47;2;93-9

  • Clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder.

    Frank RA, McRae AF, Pocklington AJ, van de Lagemaat LN, Navarro P, Croning MD, Komiyama NH, Bradley SJ, Challiss RA, Armstrong JD, Finn RD, Malloy MP, MacLean AW, Harris SE, Starr JM, Bhaskar SS, Howard EK, Hunt SE, Coffey AJ, Ranganath V, Deloukas P, Rogers J, Muir WJ, Deary IJ, Blackwood DH, Visscher PM and Grant SG

    PloS one 2011;6;4;e19011

  • Beta-adrenergic receptor activation rescues theta frequency stimulation-induced LTP deficits in mice expressing C-terminally truncated NMDA receptor GluN2A subunits.

    Moody TD, Watabe AM, Indersmitten T, Komiyama NH, Grant SG and O'Dell TJ

    Learning & memory (Cold Spring Harbor, N.Y.) 2011;18;2;118-27

  • Characterization of the proteome, diseases and evolution of the human postsynaptic density.

    Bayés A, van de Lagemaat LN, Collins MO, Croning MD, Whittle IR, Choudhary JS and Grant SG

    Nature neuroscience 2011;14;1;19-21

  • The human postsynaptic density shares conserved elements with proteomes of unicellular eukaryotes and prokaryotes.

    Emes RD and Grant SG

    Frontiers in neuroscience 2011;5;44

  • Association of mouse Dlg4 (PSD-95) gene deletion and human DLG4 gene variation with phenotypes relevant to autism spectrum disorders and Williams' syndrome.

    Feyder M, Karlsson RM, Mathur P, Lyman M, Bock R, Momenan R, Munasinghe J, Scattoni ML, Ihne J, Camp M, Graybeal C, Strathdee D, Begg A, Alvarez VA, Kirsch P, Rietschel M, Cichon S, Walter H, Meyer-Lindenberg A, Grant SG and Holmes A

    The American journal of psychiatry 2010;167;12;1508-17

  • Neuroligin 1 is dynamically exchanged at postsynaptic sites.

    Schapitz IU, Behrend B, Pechmann Y, Lappe-Siefke C, Kneussel SJ, Wallace KE, Stempel AV, Buck F, Grant SG, Schweizer M, Schmitz D, Schwarz JR, Holzbaur EL and Kneussel M

    The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30;38;12733-44

  • Genome variation and complexity in the autism spectrum.

    van de Lagemaat LN and Grant SG

    Neuron 2010;67;1;8-10

  • In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93.

    Delint-Ramirez I, Fernández E, Bayés A, Kicsi E, Komiyama NH and Grant SG

    The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30;24;8162-70

  • The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment.

    Arbuckle MI, Komiyama NH, Delaney A, Coba M, Garry EM, Rosie R, Allchorne AJ, Forsyth LH, Bence M, Carlisle HJ, O'Dell TJ, Mitchell R, Fleetwood-Walker SM and Grant SG

    EMBO reports 2010;11;6;473-8

  • Confirmed rare copy number variants implicate novel genes in schizophrenia.

    Tam GW, van de Lagemaat LN, Redon R, Strathdee KE, Croning MD, Malloy MP, Muir WJ, Pickard BS, Deary IJ, Blackwood DH, Carter NP and Grant SG

    Biochemical Society transactions 2010;38;2;445-51

  • Targeted TAP tags, phosphoproteomes and the biology of thought.

    Grant SG

    Expert review of proteomics 2010;7;2;169-71

  • Automated design of genomic Southern blot probes.

    Croning MD, Fricker DG, Komiyama NH and Grant SG

    BMC genomics 2010;11;74

  • The role of DNA copy number variation in schizophrenia.

    Tam GW, Redon R, Carter NP and Grant SG

    Biological psychiatry 2009;66;11;1005-12

  • The origin and evolution of synapses.

    Ryan TJ and Grant SG

    Nature reviews. Neuroscience 2009;10;10;701-12

  • Reciprocal regulation of microRNA and mRNA profiles in neuronal development and synapse formation.

    Manakov SA, Grant SG and Enright AJ

    BMC genomics 2009;10;419

  • Neuroproteomics: understanding the molecular organization and complexity of the brain.

    Bayés A and Grant SG

    Nature reviews. Neuroscience 2009;10;9;635-46

  • PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors.

    Abbas AI, Yadav PN, Yao WD, Arbuckle MI, Grant SG, Caron MG and Roth BL

    The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29;22;7124-36

  • Integrin-mediated axoglial interactions initiate myelination in the central nervous system.

    Câmara J, Wang Z, Nunes-Fonseca C, Friedman HC, Grove M, Sherman DL, Komiyama NH, Grant SG, Brophy PJ, Peterson A and ffrench-Constant C

    The Journal of cell biology 2009;185;4;699-712

  • Neurotransmitters drive combinatorial multistate postsynaptic density networks.

    Coba MP, Pocklington AJ, Collins MO, Kopanitsa MV, Uren RT, Swamy S, Croning MD, Choudhary JS and Grant SG

    Science signaling 2009;2;68;ra19

  • PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex.

    Zhang J, Xu TX, Hallett PJ, Watanabe M, Grant SG, Isacson O and Yao WD

    The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29;9;2948-60

  • G2Cdb: the Genes to Cognition database.

    Croning MD, Marshall MC, McLaren P, Armstrong JD and Grant SG

    Nucleic acids research 2009;37;Database issue;D846-51

  • A general basis for cognition in the evolution of synapse signaling complexes.

    Grant SG

    Cold Spring Harbor symposia on quantitative biology 2009;74;249-57

  • Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.

    Fernández E, Collins MO, Uren RT, Kopanitsa MV, Komiyama NH, Croning MD, Zografos L, Armstrong JD, Choudhary JS and Grant SG

    Molecular systems biology 2009;5;269

  • Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity.

    Carlisle HJ, Fink AE, Grant SG and O'Dell TJ

    The Journal of physiology 2008;586;24;5885-900

  • Kinase networks integrate profiles of N-methyl-D-aspartate receptor-mediated gene expression in hippocampus.

    Coba MP, Valor LM, Kopanitsa MV, Afinowi NO and Grant SG

    The Journal of biological chemistry 2008;283;49;34101-7

  • Evolutionary expansion and anatomical specialization of synapse proteome complexity.

    Emes RD, Pocklington AJ, Anderson CN, Bayes A, Collins MO, Vickers CA, Croning MD, Malik BR, Choudhary JS, Armstrong JD and Grant SG

    Nature neuroscience 2008;11;7;799-806

  • Phosphoproteomic analysis of the mouse brain cytosol reveals a predominance of protein phosphorylation in regions of intrinsic sequence disorder.

    Collins MO, Yu L, Campuzano I, Grant SG and Choudhary JS

    Molecular & cellular proteomics : MCP 2008;7;7;1331-48

  • Expression of AMPA receptor subunits at synapses in laminae I-III of the rodent spinal dorsal horn.

    Polgár E, Watanabe M, Hartmann B, Grant SG and Todd AJ

    Molecular pain 2008;4;5

  • Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes.

    Ryan TJ, Emes RD, Grant SG and Komiyama NH

    BMC neuroscience 2008;9;6

  • alpha-Isoform of calcium-calmodulin-dependent protein kinase II and postsynaptic density protein 95 differentially regulate synaptic expression of NR2A- and NR2B-containing N-methyl-d-aspartate receptors in hippocampus.

    Park CS, Elgersma Y, Grant SG and Morrison JH

    Neuroscience 2008;151;1;43-55

  • Clustered gene expression changes flank targeted gene loci in knockout mice.

    Valor LM and Grant SG

    PloS one 2007;2;12;e1303

  • NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840.

    Delgado JY, Coba M, Anderson CN, Thompson KR, Gray EE, Heusner CL, Martin KC, Grant SG and O'Dell TJ

    The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27;48;13210-21

  • Toward a molecular catalogue of synapses.

    Grant SG

    Brain research reviews 2007;55;2;445-9

  • Inhibition of the dopamine D1 receptor signaling by PSD-95.

    Zhang J, Vinuela A, Neely MH, Hallett PJ, Grant SG, Miller GM, Isacson O, Caron MG and Yao WD

    The Journal of biological chemistry 2007;282;21;15778-89

  • Network activity-independent coordinated gene expression program for synapse assembly.

    Valor LM, Charlesworth P, Humphreys L, Anderson CN and Grant SG

    Proceedings of the National Academy of Sciences of the United States of America 2007;104;11;4658-63

  • The role of neuronal complexes in human X-linked brain diseases.

    Laumonnier F, Cuthbert PC and Grant SG

    American journal of human genetics 2007;80;2;205-20

  • Integrating synapse proteomics with transcriptional regulation.

    Valor LM and Grant SG

    Behavior genetics 2007;37;1;18-30

  • Expression of transgenes targeted to the Gt(ROSA)26Sor locus is orientation dependent.

    Strathdee D, Ibbotson H and Grant SG

    PloS one 2006;1;e4

  • High throughput protein expression screening in the nervous system--needs and limitations.

    Anderson CN and Grant SG

    The Journal of physiology 2006;575;Pt 2;367-72

  • Reconstructing protein complexes: from proteomics to systems biology.

    Armstrong JD, Pocklington AJ, Cumiskey MA and Grant SG

    Proteomics 2006;6;17;4724-31

  • Recording long-term potentiation of synaptic transmission by three-dimensional multi-electrode arrays.

    Kopanitsa MV, Afinowi NO and Grant SG

    BMC neuroscience 2006;7;61

  • A novel role for cyclic guanosine 3',5'monophosphate signaling in synaptic plasticity: a selective suppressor of protein kinase A-dependent forms of long-term potentiation.

    Makhinson M, Opazo P, Carlisle HJ, Godsil B, Grant SG and O'Dell TJ

    Neuroscience 2006;140;2;415-31

  • Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome.

    Collins MO, Husi H, Yu L, Brandon JM, Anderson CN, Blackstock WP, Choudhary JS and Grant SG

    Journal of neurochemistry 2006;97 Suppl 1;16-23

  • Organization of brain complexity--synapse proteome form and function.

    Pocklington AJ, Armstrong JD and Grant SG

    Briefings in functional genomics & proteomics 2006;5;1;66-73

  • Synaptic Ras GTPase activating protein regulates pattern formation in the trigeminal system of mice.

    Barnett MW, Watson RF, Vitalis T, Porter K, Komiyama NH, Stoney PN, Gillingwater TH, Grant SG and Kind PC

    The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26;5;1355-65

  • The synapse proteome and phosphoproteome: a new paradigm for synapse biology.

    Grant SG

    Biochemical Society transactions 2006;34;Pt 1;59-63

  • The proteomes of neurotransmitter receptor complexes form modular networks with distributed functionality underlying plasticity and behaviour.

    Pocklington AJ, Cumiskey M, Armstrong JD and Grant SG

    Molecular systems biology 2006;2;2006.0023

  • Synapse proteomics of multiprotein complexes: en route from genes to nervous system diseases.

    Grant SG, Marshall MC, Page KL, Cumiskey MA and Armstrong JD

    Human molecular genetics 2005;14 Spec No. 2;R225-34

  • AMPA receptor trafficking and GluR1.

    Grant SG

    Science (New York, N.Y.) 2005;310;5746;234-5; author reply 234-5

  • Dynamic distribution of endoplasmic reticulum in hippocampal neuron dendritic spines.

    Toresson H and Grant SG

    The European journal of neuroscience 2005;22;7;1793-8

  • Robust enrichment of phosphorylated species in complex mixtures by sequential protein and peptide metal-affinity chromatography and analysis by tandem mass spectrometry.

    Collins MO, Yu L, Husi H, Blackstock WP, Choudhary JS and Grant SG

    Science's STKE : signal transduction knowledge environment 2005;2005;298;pl6

  • Differential expression of two NMDA receptor interacting proteins, PSD-95 and SynGAP during mouse development.

    Porter K, Komiyama NH, Vitalis T, Kind PC and Grant SG

    The European journal of neuroscience 2005;21;2;351-62

  • Proteomics in postgenomic neuroscience: the end of the beginning.

    Choudhary J and Grant SG

    Nature neuroscience 2004;7;5;440-5

  • The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data.

    Hermjakob H, Montecchi-Palazzi L, Bader G, Wojcik J, Salwinski L, Ceol A, Moore S, Orchard S, Sarkans U, von Mering C, Roechert B, Poux S, Jung E, Mersch H, Kersey P, Lappe M, Li Y, Zeng R, Rana D, Nikolski M, Husi H, Brun C, Shanker K, Grant SG, Sander C, Bork P, Zhu W, Pandey A, Brazma A, Jacq B, Vidal M, Sherman D, Legrain P, Cesareni G, Xenarios I, Eisenberg D, Steipe B, Hogue C and Apweiler R

    Nature biotechnology 2004;22;2;177-83

  • Synapse signalling complexes and networks: machines underlying cognition.

    Grant SG

    BioEssays : news and reviews in molecular, cellular and developmental biology 2003;25;12;1229-35

  • Systems biology in neuroscience: bridging genes to cognition.

    Grant SG

    Current opinion in neurobiology 2003;13;5;577-82

  • Phosphatidylinositol 3-kinase regulates the induction of long-term potentiation through extracellular signal-related kinase-independent mechanisms.

    Opazo P, Watabe AM, Grant SG and O'Dell TJ

    The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23;9;3679-88

  • PDZ domain proteins: plug and play!

    Nourry C, Grant SG and Borg JP

    Science's STKE : signal transduction knowledge environment 2003;2003;179;RE7

  • Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling.

    Fagiolini M, Katagiri H, Miyamoto H, Mori H, Grant SG, Mishina M and Hensch TK

    Proceedings of the National Academy of Sciences of the United States of America 2003;100;5;2854-9

  • SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor.

    Komiyama NH, Watabe AM, Carlisle HJ, Porter K, Charlesworth P, Monti J, Strathdee DJ, O'Carroll CM, Martin SJ, Morris RG, O'Dell TJ and Grant SG

    The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22;22;9721-32

  • Putting tubby on the MAP.

    Grant SG

    Nature genetics 2002;30;4;347-8

  • Proteomics in neuroscience: from protein to network.

    Grant SG and Blackstock WP

    The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21;21;8315-8

  • Proteomics of multiprotein complexes: answering fundamental questions in neuroscience.

    Grant SG and Husi H

    Trends in biotechnology 2001;19;10 Suppl;S49-54

  • Multiprotein complex signaling and the plasticity problem.

    Grant SG and O'Dell TJ

    Current opinion in neurobiology 2001;11;3;363-8

  • Proteomics of the nervous system.

    Husi H and Grant SG

    Trends in neurosciences 2001;24;5;259-66

  • Isolation of 2000-kDa complexes of N-methyl-D-aspartate receptor and postsynaptic density 95 from mouse brain.

    Husi H and Grant SG

    Journal of neurochemistry 2001;77;1;281-91

  • Targeted Gene Disruption in the CNS to Study Learning and Behavior

    Grant SGN

    Methods (San Diego, Calif.) 1996;10;3;406-16

  • Analysis of NMDA receptor mediated synaptic plasticity using gene targeting: roles of Fyn and FAK non-receptor tyrosine kinases.

    Grant SG

    Journal of physiology, Paris 1996;90;5-6;337-8

  • Fyn tyrosine kinase is required for normal amygdala kindling.

    Cain DP, Grant SG, Saucier D, Hargreaves EL and Kandel ER

    Epilepsy research 1995;22;2;107-14

  • Gene targeting and synaptic plasticity.

    Grant SG

    Current opinion in neurobiology 1994;4;5;687-92

  • Targeting learning.

    Grant SG and Silva AJ

    Trends in neurosciences 1994;17;2;71-5

  • Analysis of somatic cell mutations at the glycophorin A locus in atomic bomb survivors: a comparative study of assay methods.

    Langlois RG, Akiyama M, Kusunoki Y, DuPont BR, Moore DH, Bigbee WL, Grant SG and Jensen RH

    Radiation research 1993;136;1;111-7

  • Proto-oncogenes and signaling processes in neural tissues.

    Sudol M, Grant SG and Maisonpierre PC

    Neurochemistry international 1993;22;4;369-84

  • Activation of cAMP-responsive genes by stimuli that produce long-term facilitation in Aplysia sensory neurons.

    Kaang BK, Kandel ER and Grant SG

    Neuron 1993;10;3;427-35

  • The mas proto-oncogene is developmentally regulated in the rat central nervous system.

    Martin KA, Grant SG and Hockfield S

    Brain research. Developmental brain research 1992;68;1;75-82

  • Overexpression of an Aplysia shaker K+ channel gene modifies the electrical properties and synaptic efficacy of identified Aplysia neurons.

    Kaang BK, Pfaffinger PJ, Grant SG, Kandel ER and Furukawa Y

    Proceedings of the National Academy of Sciences of the United States of America 1992;89;3;1133-7

  • Pharmacological and genetic approaches to the analysis of tyrosine kinase function in long-term potentiation.

    O'Dell TJ, Grant SG, Karl K, Soriano PM and Kandel ER

    Cold Spring Harbor symposia on quantitative biology 1992;57;517-26

  • Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors.

    O'Dell TJ, Kandel ER and Grant SG

    Nature 1991;353;6344;558-60

  • Somatic cell genotoxicity at the glycophorin A locus in humans.

    Jensen RH, Grant SG, Langlois RG and Bigbee WL

    Progress in clinical and biological research 1991;372;329-39

  • Localization of the mouse Mcf-2 (Dbl) protooncogene within a conserved linkage group on the mouse X chromosome.

    Grant SG, Mattei MG, Galland F, Stephenson DA, Keitz BT, Birnbaum D and Chapman VM

    Cytogenetics and cell genetics 1990;54;3-4;175-81

  • Long-term facilitation in Aplysia: persistent phosphorylation and structural changes.

    Schacher S, Glanzman D, Barzilai A, Dash P, Grant SG, Keller F, Mayford M and Kandel ER

    Cold Spring Harbor symposia on quantitative biology 1990;55;187-202

  • cis-acting determinants of basal and lipid-regulated apolipoprotein A-IV expression in mice.

    Williams SC, Grant SG, Reue K, Carrasquillo B, Lusis AJ and Kinniburgh AJ

    The Journal of biological chemistry 1989;264;32;19009-16

© G2C 2014. The Genes to Cognition Programme received funding from The Wellcome Trust and the EU FP7 Framework Programmes:
EUROSPIN (FP7-HEALTH-241498), SynSys (FP7-HEALTH-242167) and GENCODYS (FP7-HEALTH-241995).

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