G2Cdb::Allele report

Mutation type

Altered genes (1)

Gene Symbol Species Description
G00001468 RAB3A Homo sapiens RAB3A, member RAS oncogene family

Diseases (1)

Disease Description Nervous effect
D00000177 Autism Y

Literature (1)

Pubmed - other

  • DNA variants in the human RAB3A gene are not associated with autism.

    D'Adamo P, Bacchelli E, Blasi F, Lipp HP, Toniolo D and Maestrini E

    Institute of Anatomy, University of Zurich, Switzerland. p.dadamo@anatom.unizh.ch.

    Mutation screening of the RAB3A gene in 47 individuals with autism provided no evidence that DNA variants in this gene are associated with autism. Since Rab3a constitutive knockout mice react to novel stimuli with hyperactivity, a further search for association of RAB3A DNA variants with other neurobehavioral disorders such as attention deficit/hyperactivity disorder appears justified.

    Funded by: Telethon: E.1007, GGP030192

    Genes, brain, and behavior 2004;3;2;123-4

© G2C 2014. The Genes to Cognition Programme received funding from The Wellcome Trust and the EU FP7 Framework Programmes:
EUROSPIN (FP7-HEALTH-241498), SynSys (FP7-HEALTH-242167) and GENCODYS (FP7-HEALTH-241995).

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