G2Cdb::Human Disease report

Disease id
D00000086
Name
Malignant lymphoma
Nervous system disease
no

Genes (1)

Gene Name/Description Mutations Found Literature Mutations Type Genetic association?
G00000031 HRAS
v-Ha-ras Harvey rat sarcoma viral oncogene homolog
Y (8104094) Deletion (D) Y

References

  • Rare HRAS1 alleles outside the VTR region in lymph nodes from patients with malignant lymphoma.

    Stul M, Baens M, Mecucci C, Van den Berghe H and Cassiman JJ

    Center for Human Genetics, University of Leuven, Belgium.

    We found a new type of rare HRAS1 alleles arising de novo in the lymph node of lymphoma patients. Rare alleles of 6.2 kb (a0.1) and 7.3 kb (a2.3) are displayed in the presence of common alleles of 6.6 kb (a1) and 7.6 kb (a3), respectively. These rare alleles lack nucleotide sequences, present in the common alleles in the 5' part between the BamHI and XmaIII site. In addition, the rare alleles may have the classic A-G mutation in the intron at position 2719. In contrast to what is observed for rare constitutional alleles, the VTR region of these rare alleles has the same size as the common alleles. At present the significance of this new type of alleles is not clear.

    Cancer genetics and cytogenetics 1993;69;1;60-4

Literature (1)

Pubmed - human_disease

  • Rare HRAS1 alleles outside the VTR region in lymph nodes from patients with malignant lymphoma.

    Stul M, Baens M, Mecucci C, Van den Berghe H and Cassiman JJ

    Center for Human Genetics, University of Leuven, Belgium.

    We found a new type of rare HRAS1 alleles arising de novo in the lymph node of lymphoma patients. Rare alleles of 6.2 kb (a0.1) and 7.3 kb (a2.3) are displayed in the presence of common alleles of 6.6 kb (a1) and 7.6 kb (a3), respectively. These rare alleles lack nucleotide sequences, present in the common alleles in the 5' part between the BamHI and XmaIII site. In addition, the rare alleles may have the classic A-G mutation in the intron at position 2719. In contrast to what is observed for rare constitutional alleles, the VTR region of these rare alleles has the same size as the common alleles. At present the significance of this new type of alleles is not clear.

    Cancer genetics and cytogenetics 1993;69;1;60-4

© G2C 2014. The Genes to Cognition Programme received funding from The Wellcome Trust and the EU FP7 Framework Programmes:
EUROSPIN (FP7-HEALTH-241498), SynSys (FP7-HEALTH-242167) and GENCODYS (FP7-HEALTH-241995).

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