G2Cdb::Gene report

Gene id: G00001624
Gene symbol: PIK3CA (HGNC)
Species: Homo sapiens
Description: phosphoinositide-3-kinase, catalytic, alpha polypeptide
Orthologue: G00000375 (Mus musculus)

Databases (7)
Synonyms (1)
Diseases (45)
Literature (308)
Gene lists (4)

Databases (7)

Gene: ENSG00000121879 (Ensembl human gene); 5290 (Entrez Gene); 379 (G2Cdb plasticity & disease); PIK3CA (GeneCards)
Literature: 171834 (OMIM)
Marker Symbol: HGNC:8975 (HGNC)
Protein Sequence: P42336 (UniProt)

Synonyms (1)

PI3K

Diseases (45)

Disease	Nervous effect	Mutations Found	Literature	Mutations Type	Genetic association?
D00000321: Cancer	N	Y	(15016963)	Unknown (?)	Y
D00000042: Breast cancer	N	Y	(15254419)	Unknown (?)	Y
D00000067: Oligodendroglioma (anaplastic)	Y	Y	(15289301)	Unknown (?)	Y
D00000068: Astrocytoma (anaplastic)	Y	Y	(15289301)	Unknown (?)	Y
D00000073: Glioblastoma multiforme	Y	Y	(15289301)	Unknown (?)	Y
D00000074: Medulloblastoma	N	Y	(15289301)	Unknown (?)	Y
D00000071: Ependymoma	Y	Y	(15289301)	Unknown (?)	N
D00000069: Astrocytoma (low grade)	Y	Y	(15289301)	Unknown (?)	N
D00000021: Colon cancer	N	Y	(15467468)	Unknown (?)	Y
D00000042: Breast cancer	N	Y	(15467468)	Unknown (?)	Y
D00000070: Brain tumours (various)	Y	Y	(15467468)	Unknown (?)	Y
D00000028: Lung cancer	N	Y	(15467468)	Unknown (?)	Y
D00000049: Ovarian cancer	N	Y	(15520168)	Unknown (?)	Y
D00000042: Breast cancer	N	Y	(15520168)	Unknown (?)	Y
D00000105: Breast carcinoma	N	Y	(15608678)	Unknown (?)	Y
D00000027: Hepatocellular carcinoma	N	Y	(15608678)	Unknown (?)	Y
D00000050: Ovarian carcinoma	N	Y	(15712344)	Microinsertion (MI)	?
D00000017: Gastric adenocarcinoma	N	Y	(15784156)	Unknown (?)	Y
D00000105: Breast carcinoma	N	Y	(15805248)	Unknown (?)	Y
D00000047: Epithelial ovarian carcinoma	N	Y	(15837735)	Microinsertion (MI)	Y
D00000107: Invasive breast carcinoma	N	Y	(15837735)	Microinsertion (MI)	Y
D00000072: Glioblastoma	Y	Y	(15924252)	No mutation found (N)	N
D00000073: Glioblastoma multiforme	Y	Y	(15924253)	Unknown (?)	Y
D00000081: Thyroid cancer	N	Y	(15928251)	Single nucleotide polymorphism (SNP)	?
D00000019: Gastric carcinoma	N	Y	(15994075)	Unknown (?)	Y
D00000023: Colorectal carcinoma	N	Y	(15994075)	Unknown (?)	Y
D00000014: Nasopharyngeal carcinoma	N	Y	(16114017)	Unknown (?)	?
D00000072: Glioblastoma	Y	Y	(16150119)	Unknown (?)	Y
D00000042: Breast cancer	N	Y	(16168105)	Unknown (?)	Y
D00000049: Ovarian cancer	N	Y	(16203798)	Microinsertion (MI)	Y
D00000079: Anaplastic thyroid cancer	N	Y	(16288007)	Unknown (?)	Y
D00000045: Endometrial carcinoma	N	Y	(16322209)	Microinsertion (MI)	Y
D00000026: Hepatoblastular carcinoma	N	Y	(16331247)	No mutation found (N)	N
D00000105: Breast carcinoma	N	Y	(16353168)	Unknown (?)	Y
D00000015: Oesophageal squamous cell carcinoma	N	Y	(16380997)	Unknown (?)	Y
D00000002: Adenocarcinoma	N	Y	(16380997)	Unknown (?)	Y
D00000243: Barrett's oesophagus	N	Y	(16380997)	Unknown (?)	N
D00000115: Meningioma	N	Y	(16463202)	Unknown (?)	?
D00000036: Head and neck squamous cell carcinoma	N	Y	(16533766)	Microinsertion (MI)	Y
D00000033: Cutaneous melanoma	N	Y	(16567976)	Microinsertion (MI)	Y
D00000093: Acute myeloid leukaemia	N	Y	(16573740)	No mutation found (N)	N
D00000042: Breast cancer	N	Y	(16582596)	Single nucleotide polymorphism (SNP)	Y
D00000075: Oligodendroglial tumour	Y	Y	(16599949)	Unknown (?)	?
D00000055: Ovarian serous carcinoma	N	Y	(16721043)	Unknown (?)	?
D00000056: Serous borderline tumour	N	Y	(16721043)	Unknown (?)	?
D00000044: Endometrial cancer	N	Y	(16764926)	Microinsertion (MI)	Y
D00000044: Endometrial cancer	N	Y	(16764926)	Polymorphism (P)	Y
D00000011: Osteosarcoma	N	Y	(16764926)	Microinsertion (MI)	Y
D00000011: Osteosarcoma	N	Y	(16764926)	Polymorphism (P)	Y
D00000093: Acute myeloid leukaemia	N	Y	(16764926)	Microinsertion (MI)	N
D00000093: Acute myeloid leukaemia	N	Y	(16764926)	Polymorphism (P)	N
D00000031: Intraductal papillary mucinous neoplasm	N	Y	(16778113)	Microinsertion (MI)	Y
D00000030: Intraductal papillary mucinous carcinoma	N	Y	(16778113)	Microinsertion (MI)	Y
D00000066: Neuroblastoma	Y	Y	(16822308)	Microinsertion (MI)	?
D00000061: Superficial papillary bladder tumour	N	Y	(16885334)	Unknown (?)	Y
D00000028: Lung cancer	N	Y	(16930767)	Microinsertion (MI)	Y
D00000045: Endometrial carcinoma	N	Y	(16949921)	Unknown (?)	Y
D00000073: Glioblastoma multiforme	Y	Y	(17050665)	Unknown (?)	Y
D00000016: Oral squamous cell carcinoma	N	Y	(17052259)	Microinsertion (MI)	Y
D00000046: Uterine endometrioid carcinoma	N	Y	(17062663)	Unknown (?)	Y
D00000274: Complex atypical hyperplasia	N	Y	(17062663)	Unknown (?)	N
D00000105: Breast carcinoma	N	Y	(17202311)	Microinsertion (MI)	Y
D00000014: Nasopharyngeal carcinoma	N	Y	(17222361)	Microinsertion (MI)	Y
D00000072: Glioblastoma	Y	Y	(17235514)	Microinsertion (MI)	Y
D00000081: Thyroid cancer	N	Y	(17317825)	Duplication (Du)	Y

References

Literature (308)

Pubmed - human_disease

Pubmed - other

Gene lists (4)

Gene List	Source	Species	Name	Description	Gene count
L00000009	G2C	Homo sapiens	Human PSD	Human orthologues of mouse PSD adapted from Collins et al (2006)	1080
L00000015	G2C	Homo sapiens	Human NRC	Human orthologues of mouse NRC adapted from Collins et al (2006)	186
L00000016	G2C	Homo sapiens	Human PSP	Human orthologues of mouse PSP adapted from Collins et al (2006)	1121
L00000034	G2C	Homo sapiens	Pocklington H3	Human orthologues of cluster 3 (mouse) from Pocklington et al (2006)	30