G2C::PhosphoProteomics

Neurotransmitters Drive Combinatorial Multistate Postsynaptic Density Networks

Coba MP1, Pocklington AJ2, Collins MO3, Kopanitsa MV1, Uren RT1, Swamy S3, Croning MD1, Choudhary JS3, Grant SG1.

Author email: sg3@sanger.ac.uk

  1. Genes to Cognition, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
  2. Institute for Adaptive and Neural Computation, Division of Informatics, University of Edinburgh, 5 Forrest Hill, Edinburgh EH1 2QL, UK.
  3. Proteomic Mass Spectrometry, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.

Synapse phosphoproteome mapping resource

Synapse phosphoproteome mapping resource

Synapse phosphoproteome mapping resource
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The synapse is a subcellular compartment housing a remarkably diverse set of signaling proteins. Neurotransmitters activate phosphorylation and dephosphorylation of intracellular proteins and these processes are at the centre of understanding the regulation of synaptic transmission, plasticity, forms of behaviour including learning and addiction, as well as contributing to numerous diseases.

We have generated a resource for mapping the complexity of postsynaptic signaling by combining mass spectrometry data from mouse brain, which identifies the state of phosphorylation of specific sites on substrates, with peptide array mapping, which identifies the kinases responsible for phosphorylating specific sites. Details of the data and methods are found in Coba et al, (Mapping postsynaptic phosphoproteome networks: integration and switching mechanisms underlying NMDA receptor signaling, submitted). This resource is embedded in G2Cdb so that data can be linked to phenotype data in mice and humans and other datasets in G2Cdb (and its external links). A set of frequently asked questions (FAQs) is presented to illustrate some of the major uses of the resource, and it is recommended that users click on the FAQs and then bookmark specific tables.

Data resources

1. Is this substrate phosphorylated in vivo, where are the sites, which kinases phosphorylate that site?

Unable to read file: psd-95.png

Go to Table 1 and scroll down for the name or ID of the protein (example screen below). For each protein substrate all the sites that were mapped, the number of kinases and their specific names for each site are shown. Also included is literature reference (PubMed PMID or link) and position of site as referred to in this publication.

Using PSD-95 as an example substrate, there are 9 reported phosphorylation sites (T19, S25, S35, T287, T290, S295, S415, S418, Y432).

2. What are the synaptic substrates for this kinase?

Unable to read file: camkii.png

Go to Table 2 to see list of kinases and the substrates and sites. For example, CamkII (which is important in synaptic plasticity and learning) has 16 identified substrates.

3. Which proteins are phosphorylated and dephosphorylated when the NMDA receptor is stimulated?

Go to Table 3 to see list of substrates and if they were found to be dephosphorylated or phosphorylated after NMDA stimulation of hippocampus.

4. What does a synaptic phosphoproteome network look like?

The kinase-substrate data can be graphed to show the complexity of the postsynaptic phosphorylation networks.

5. How do I find out if this kinase or substrate is required for synaptic plasticity in mutant mice?

G2Cdb is an integrated database for studying neurobiology and contains data on mouse knockouts and synaptic plasticity. This is a curated database of literature and data directly deposited from the Genes to Cognition mutant mouse phenotyping pipeline. Links from the substrates and kinases described in these synapse phosphoproteome pages to this data can be found via the G2Cdb gene name links provided in the tables.

6. Is this kinase or substrate involved in a human disease?

G2Cdb also contains information on synaptic genes and their involvement in disease as well as links to OMIM. We have focussed the disease curated literature on components of the postsynaptic proteome, particularly components of the NRC/MASC complexes. Links from the substrates and kinases described in these synapse phosphoproteome pages to this data can be found via the G2Cdb gene name links provided in the tables.

7. Where do I find a detailed description of the methods and results for mapping synapse phosphorylation networks?

Table 1. Substrate phosphorylation sites and their cognate kinases

The protein substrate name and identifiers (G2Cdb gene ID and Uniprot accession) are shown. The specific site in that substrate is indicated (e.g. S184) and where a sequence is shown (e.g. FYYEILNSPEKACSL) this indicates that the specific phosphoacceptor residue was not unambiguously defined within that sequence. The number of kinases phosphorylated that site/sequence and names is shown. Links to literature and mouse genetic and human disease data is obtained via the G2Cdb gene link.

Substrate G2Cdb gene UniProt Site/sequence N kinases Kinases Literature
14-3-3 zeta G00001286 P63101 S184 4 CKI, Erk2, Cdk5, TBKI 15071501
14-3-3 zeta G00001286 P63101 S58 10 CamkII, CKI, Erk2, Akt1, PKC-alpha, PKC-delta, PKC-zeta, p70S6K, PKA, TBKI 11956222
14-3-3 zeta G00001286 P63101 S57 4 CKI, Erk1, PKC-delta, PKC-zeta novel
14-3-3 zeta G00001286 P63101 FYYEILNSPEKACSL 4 fyn, Src, Pyk2, fes
14-3-3 zeta G00001286 P63101 VVGARRSSWRVVSSI 1 RSK-2
Adenylate cyclase type IX P51830 S610 2 Erk2, GSK3-beta 15572359
Adenylate cyclase type IX P51830 S613 2 Erk2, GSK3-beta 15572359
Adenylate cyclase type IX P51830 RGQGTASPGSVSDLA 1 TBKI
Ankyrin2 G00000576 Q01484 S2439 1 Cdk5 15572359
Ankyrin2 G00000576 Q01484 S31 4 CamkII, PKC-alpha, PKC-delta, RSK-2 15572359
Ankyrin2 G00000576 Q01484 S34 5 CamkII, PKC-alpha, PKC-delta, PKC-zeta, TBKI 15572359
Ankyrin2 G00000576 Q01484 PKKSDSNASFLRAAR 1 CamkII
Band 4.1like protein1 G00000593 Q9Z2H5 S466 1 p70S6K 15572359
Band 4.1like protein1 G00000593 Q9Z2H5 S648 1 CK2 15572359
Band 4.1like protein1 G00000593 Q9Z2H5 S650 1 CK2 15572359
Band 4.1like protein1 G00000593 Q9Z2H5 T475 3 Erk2, Erk1, p38-alpha 15572359
Band 4.1like protein1 G00000593 Q9Z2H5 PELDRDKSDSETEGL 1 CKI
Bassoon G00000957 O88737 S1415 1 RSK-2 15572359
Bassoon G00000957 O88737 S1417 2 CKI, RSK-2 15572359
Bassoon G00000957 O88737 S1418 2 Cdk5, p70S6K 15572359
Bassoon G00000957 O88737 S1509 2 CKI, Erk2 15572359
Bassoon G00000957 O88737 S2121 1 PKA 15572359
Bassoon G00000957 O88737 S2865 1 p38-alpha 15572359
Bassoon G00000957 O88737 S3213 1 PKA 15572359
Bassoon G00000957 O88737 S3217 6 Erk2, Erk1, GSK3-beta, Cdk5, p38-alpha, TBKI 15572359
Bassoon G00000957 O88737 T1510 1 p70S6K 15572359
Bassoon G00000957 O88737 T2904 3 Erk2, Erk1, p38-alpha 15572359
Bassoon G00000957 O88737 Y1423 3 Src, Pyk2, fes novel
Bassoon G00000957 O88737 ERSPSTSSTIHSYGQ 1 TBKI
Bassoon G00000957 O88737 KTLQRSLSDPKPLSP 1 Erk1
Bassoon G00000957 O88737 PRATAEFSTQTPSLT 2 GSK3-beta, TBKI
b-Catenin G00000986 Q02248 S33 1 GSK3-beta 12051714
b-Catenin G00000986 Q02248 Y654 4 fyn, Src, Pyk2, fes 11279024
b-Catenin G00000986 Q02248 Y86 4 fyn, Src, Pyk2, fes 11279024
b-Catenin G00000986 Q02248 T653 2 Erk2, PKA novel
b-Catenin G00000986 Q02248 QSYLDSGIHSGATTT 2 CKI, GSK3-beta
Brain specific p25a G00000908 Q7TQD2 S19 1 CamkII 15572359
Ca-Activated K Channel-alpha1 G00000087 Q08460 S711 3 Erk2, Erk1, Cdk5 15572359
Ca-Activated K Channel-alpha1 G00000087 Q08460 S923 1 GSK3-beta 15572359
Ca-Activated K Channel-alpha1 G00000087 Q08460 S924 1 GSK3-beta 15572359
Ca-Activated K Channel-alpha1 G00000087 Q08460 T709 1 PKC-delta 15572359
Calmodulin G00001122 P62204 S81 1 CKI 92065884
Calmodulin G00001122 P62204 T44 1 GSK3-beta DOI=10.1016/S0003-9861(02)00514
Calmodulin G00001122 P62204 T79 1 CKI 92065884
Calmodulin G00001122 P62204 Y138 4 fyn, Src, Pyk2, fes 92065884
Calmodulin G00001122 P62204 KDGDGTITTKELGTV 2 CKI, p38-alpha
Calpain-1 O35350 S379 12 c-Raf, Erk2, Akt1, MEK1, PKC-alpha, PKC-delta, PKC-zeta, p38-alpha, p70S6K, PKA, Rock-2, RSK-2 12843408
Calpain-1 O35350 T380 12 CamkII, c-Raf, Erk2, Akt1, MEK1, PKC-alpha, PKC-delta, PKC-zeta, p38-alpha, p70S6K, Rock-2, RSK-2 12843408
Calpain-1 O35350 Y387 4 fyn, Src, Pyk2, fes novel
Calpain-1 O35350 GTWRRGSTAGGCRNY 1 PKA
Calpain-m (2) O08529 GALFQDPSFPALPSS 1 TBKI
CAMKII-beta G00000151 P28652 S315 1 PKA 2162838DOI=10.1074/jbc.M411220200
CAMKII-beta G00000151 P28652 T321 3 Erk2, Erk1, Cdk5 15572359
cAMP-dependent protein kinase type II-alpha regulatory 1.Chain P12367 S75 2 CK2, CKI 15572359
cAMP-dependent protein kinase type II-alpha regulatory 1.Chain P12367 S77 1 CK2 15572359
Cortactin G00000958 Q60598 Y421 4 fyn, Src, Pyk2, fes 10921917
Cortactin G00000958 Q60598 Y466 1 fes 10921917
Cortactin G00000958 Q60598 RPPSSPIYEDAAPFK 3 Erk2, Erk1, p38-alpha
cPLA2 G00000365 P47713 S437 2 CK2, Cdk5 15592455
cPLA2 G00000365 P47713 S505 5 Erk2, Erk1, GSK3-beta, JNK3, p38-alpha 9468497
cPLA2 G00000365 P47713 S726 1 p70S6K 9468497
cPLA2 G00000365 P47713 LNTSYPLSPLRDFSS 3 CKI, PKA, TBKI
cPLA2 G00000365 P47713 RQNPSRCSVSLSNVE 1 CKI
DARPP32 G00001066 Q60829 T34 9 Erk2, Erk1, Cdk5, JNK3, PKC-alpha, PKC-delta, p38-alpha, PKA, Rock-2 DOI=10.1016/j.neuropharm.2004.05.010
DARPP32 G00001066 Q60829 T75 1 Cdk5 DOI=10.1016/j.neuropharm.2004.05.010
d-Catenin-2 G00000554 O35927 S531 3 CKI, PKC-alpha, PKA 15572359
d-Catenin-2 G00000554 O35927 S534 2 CKI, TBKI 15572359
DISKS large-associated protein 2 G00000132 Q8BJ42 S440 3 Akt1, PKC-alpha, PKA 15572359
DISKS large-associated protein 2 G00000132 Q8BJ42 S450 4 CKI, Erk2, Erk1, p38-alpha 15572359
Drebrin G00000573 Q9QXS6 S141 6 Erk2, Erk1, Cdk5, MEK1, p38-alpha, p70S6K 15572359
Drebrin G00000573 Q9QXS6 S140 9 Erk2, Erk1, JNK3, MEK1, PKC-alpha, PKC-delta, PKC-zeta, p38-alpha, PKA novel
eNOS G00000995 P70313 S613 2 p70S6K, RSK-2 12171920
eNOS G00000995 P70313 S631 1 p70S6K 12171920
eNOS G00000995 P70313 S1177 3 CKI, p70S6K, RSK-2 novel
FAK G00000014 P34152 S770 1 Cdk5 14712065
GABA-B R2 G00000067 O88871 S892 2 PKC-zeta, PKA link
GLUR1 G00000013 P23818 S710 4 Akt1, PKC-alpha, PKC-delta, PKC-zeta 8848293
GLUR1 G00000013 P23818 S849 1 CamkII DOI=10.1016/j.neures.2003.09.009
GLUR1 G00000013 P23818 S863 1 PDK-1 9405465
GLUR1 G00000013 P23818 T858 1 p70S6K 17114649
GLUR1 G00000013 P23818 GMIRVRKSKGKYAYL 5 fyn, Src, Pyk2, fes, MEK1
GLUR2 G00000058 P23819 S683 1 CamkII 8848293
GLUR2 G00000058 P23819 S717 6 Akt1, PKC-alpha, PKC-delta, PKC-zeta, Rock-2, RSK-2 8848293
GLUR2 G00000058 P23819 S863 1 CKI DOI=10.1016/S0028-3908(01)00129-0
GLUR2 G00000058 P23819 S880 5 Erk2, Erk1, GSK3-beta, Cdk5, p38-alpha 11007883
GLUR2 G00000058 P23819 Y869 5 fyn, Src, Pyk2, fes, MEK1 14976558
GLUR2 G00000058 P23819 GVARVRKSKGKYAYL 5 fyn, Src, Pyk2, fes, MEK1
GLUR2 G00000058 P23819 NPSSSQNSQNFATYK 3 CKI, c-Raf, Cdk5
GLUR2 G00000058 P23819 YKEGYNVYGIESVKI 4 fyn, Src, Pyk2, fes
GLUR4 G00000060 Q9Z2W8 S862 1 GSK3-beta link
GSK3-beta G00000171 Q9WV60 RGEPNVSYICSRYYR 2 CK2, JNK3
Guanine nucleotide-binding protein 3 Q8BH66 WGGFSEKSSDWSSEE 2 CKI, PKC-alpha
IRS1 G00000915 P35569 S24 9 CamkII, Erk2, Akt1, Cdk5, MEK1, PKC-alpha, PKC-delta, PKC-zeta, Rock-2 8349691
IRS1 G00000915 P35569 S265 3 Akt1, PKA, RSK-2 12351658
IRS1 G00000915 P35569 S267 1 p70S6K 12351658
IRS1 G00000915 P35569 S269 1 CKI 12351658
IRS1 G00000915 P35569 S302 1 p70S6K 11701324
IRS1 G00000915 P35569 S99 1 CK2 8349691
IRS1 G00000915 P35569 Y1173 2 Pyk2, fes 7504175
IRS1 G00000915 P35569 Y1220 4 fyn, Src, Pyk2, fes 12220227
IRS1 G00000915 P35569 Y460 1 fes 7504175
IRS1 G00000915 P35569 Y891 2 Src, fes 7504175
IRS1 G00000915 P35569 Y983 4 fyn, Src, Pyk2, fes 7504175
IRS1 G00000915 P35569 S105 2 CKI, c-Raf novel
IRS1 G00000915 P35569 S612 3 Erk2, Erk1, p38-alpha 15821749
IRS1 G00000915 P35569 S632 4 Erk2, Erk1, GSK3-beta, p38-alpha 11287630
IRS1 G00000915 P35569 S887 3 Erk2, GSK3-beta, TBKI novel
IRS1 G00000915 P35569 NLHTDDGYMPMSPGV 3 GSK3-beta, Cdk5, Rock-2
IRS1 G00000915 P35569 PRSKSQSSSSCSNPI 2 CKI, p70S6K
IRS1 G00000915 P35569 SSEDLSNYASISFQK 8 CK2, CKI, PKC-alpha, PKC-delta, PKC-zeta, p70S6K, PKA, RSK-2
IRS1 G00000915 P35569 TESITATSPASMVGG 3 Erk2, p38-alpha, TBKI
IRS1 G00000915 P35569 VPNSRGDYMTMQIGC 1 CKI
MAP1B G00000549 P14873 S1775 4 Erk2, Erk1, Cdk5, p38-alpha 15572359
MAP2 G00000547 P20357 S1161 1 TBKI 15572359
MAP2 G00000547 P20357 S1800 4 CKI, PKC-alpha, p70S6K, RSK-2 15572359
MAP2 G00000547 P20357 S1799 3 CKI, p70S6K, RSK-2 novel
MAP2 G00000547 P20357 S1801 2 CKI, TBKI novel
MAP2 G00000547 P20357 SMDEGDDYLPPTTPA 4 Erk2, Erk1, GSK3-beta, p38-alpha
MBP G00000558 P04370 S144 2 PKC-alpha, PKA 15572359
mGlur2 G00001238 P31421 S843 1 PKA 10366608
mGlur3 G00000062 Q9QYS2 S845 1 GSK3-beta link
mGlur4a G00001124 P31423 S859 9 CamkII, Akt1, PKC-alpha, PKC-delta, PKC-zeta, p38-alpha, p70S6K, PKA, Rock-2 14663150
mGlur4a G00001124 P31423 T865 1 p38-alpha novel
mGlur5 G00000064 P31424 S1014 4 Erk2, Erk1, Cdk5, p38-alpha 15572359
mGlur5 G00000064 P31424 S1016 4 Erk2, Erk1, Cdk5, p38-alpha 15572359
mGlur5 G00000064 P31424 AAARPRSPSPISTLS 1 TBKI
mGlur7a G00000065 Q68ED2 S862 8 CamkII, Akt1, PKC-alpha, PKC-delta, PKC-zeta, p70S6K, PKA, Rock-2 14663150
mGlur7a G00000065 Q68ED2 T868 1 p38-alpha novel
mKIAA0942 protein G00001270 Q8CEA6 S46 2 PKC-alpha, PKA 15572359
mKIAA0942 protein G00001270 Q8CEA6 T48 1 RSK-2 15572359
mKIAA0942 protein G00001270 Q8CEA6 TISRIGSTTNPFLDI 3 CKI, Akt1, TBKI
nArgbp2 O35413 S844 3 PKA, RSK-2, TBKI 15572359
nArgbp2 O35413 S849 1 TBKI novel
nArgbp2 O35413 KAEKRRGSLPDNSIL 1 CKI
Neurofascin precursor G00000561 Q810U3 ETEGNESSEATSPVN 1 MEK1
Neuromodulin G00000242 P06837 AATKIQASFRGHITR 1 CK2
Neuromodulin G00000242 P06837 KATTDNSPSSKAED 1 CKI
nNOS G00000005 Q9Z0J4 S1412 1 CKI 11052978
nNOS G00000005 Q9Z0J4 S374 1 CamkII 92096008
nNOS G00000005 Q9Z0J4 S847 3 CKI, Erk2, Rock-2 14722119
nNOS G00000005 Q9Z0J4 SYKVRFNSVSSYSDS 3 p70S6K, RSK-2, TBKI
nNOS G00000005 Q9Z0J4 TNRLRSESIAFIEES 1 CamkII
NR1 G00000849 P35438 S889 8 c-Raf, Akt1, Cdk5, MEK1, PKC-alpha, PKC-delta, PKC-zeta, Rock-2 8316301
NR1 G00000849 P35438 S890 6 c-Raf, Akt1, PKC-alpha, PKC-delta, PKC-zeta, Rock-2 8316301
NR1 G00000849 P35438 S896 1 p70S6K 8316301
NR1 G00000849 P35438 S897 2 p70S6K, PKA 8316301
NR2A G00000001 P35436 S1232 3 Erk2, Erk1, Cdk5 11675505
NR2A G00000001 P35436 GRCPSDPYKHSLPSQ 4 CKI, p70S6K, PKA, RSK-2
NR2B G00000002 Q01097 S1303 4 CamkII, c-Raf, PKA, RSK-2 8940188DOI=10.1074/mcp.T500041-MCP200
NR2B G00000002 Q01097 Y1336 4 fyn, Src, Pyk2, fes 11024032
NR2B G00000002 Q01097 Y1472 4 fyn, Src, Pyk2, fes 1102403212451687
NR2B G00000002 Q01097 T1306 1 TBKI novel
NR2B G00000002 Q01097 Y1304 4 fyn, Src, Pyk2, fes novel
NR2B G00000002 Q01097 CKKAGNLYDISEDNS 1 CKI
NR2B G00000002 Q01097 SSNGHVYEKLSSIES 3 CK2, CKI, TBKI
Paralemmin G00000586 Q9Z0P4 S152 1 Erk2 15572359
Paralemmin G00000586 Q9Z0P4 S157 4 Erk2, Erk1, GSK3-beta, Cdk5 15572359
Paralemmin G00000586 Q9Z0P4 T141 2 Cdk5, p38-alpha 15572359
Paralemmin G00000586 Q9Z0P4 T145 2 Erk2, Cdk5 15572359
PDK-1 G00000184 Q9Z2A0 Y376 4 fyn, Src, Pyk2, fes 11481331
PDK-1 G00000184 Q9Z2A0 Y379 4 fyn, Src, Pyk2, fes 11481331
PDK-1 G00000184 Q9Z2A0 Y9 2 Pyk2, fes 11481331
PDK-1 G00000184 Q9Z2A0 S384 4 c-Raf, Erk2, Cdk5, TBKI novel
Pi3K-85 P26450 Y368 1 fes 8385099
Pi3K-85 P26450 Y607 3 fyn, Pyk2, fes 9446654DOI=10.1038/nbt1046
Pi3K-85 P26450 Y688 4 fyn, Src, Pyk2, fes 9461588
Pi3K-85 P26450 FAEPYNLYSSLKELV 1 TBKI
Piccolo G00000864 Q9QYX7 S4260 1 Erk2 15572359
Piccolo G00000864 Q9QYX7 S4263 1 Erk2 15572359
Piccolo G00000864 Q9QYX7 Y3867 1 Pyk2 novel
Piccolo G00000864 Q9QYX7 AQNSEEESPLSPVGQ 1 TBKI
Piccolo G00000864 Q9QYX7 PTAVSLYSPTDEQSV 1 CKI
PKC-delta P28867 Y52 1 fes 11927579
PKC-delta P28867 Y523 1 fes 9326592
PKC-delta P28867 T50 2 CamkII, PDK-1 novel
PKC-delta P28867 EILQGLKYSFSVDWW 10 c-Raf, Erk2, Erk1, Cdk5, JNK3, PKC-alpha, PKC-delta, p38-alpha, PKA, RSK-2
PKC-delta P28867 VQKKPTMYPEWKTTF 3 CKI, MEK1, PDK-1
PKC-iota Q62074 Y116 3 fyn, Src, fes 11713277
PKC-iota Q62074 Y255 2 fes, MEK1 11713277
PKC-iota Q62074 Y270 2 fyn, Src 11713277
PKC-iota Q62074 S114 3 c-Raf, Erk2, MEK1 novel
PKC-iota Q62074 S254 6 Akt1, MEK1, PKC-alpha, PKC-delta, PKC-zeta, PKA novel
PKC-iota Q62074 T266 3 MEK1, PKC-zeta, Rock-2 novel
Plakophilin 4 G00000595 Q99569 S512 1 CKI 15572359
PLC-beta1 G00000355 Q9Z1B3 Y334 1 fes 15572359
PLC-gamma1 G00002165 P19174 Y1253 4 fyn, Src, Pyk2, fes 96108162
PLC-gamma1 G00002165 P19174 Y771 4 fyn, Src, Pyk2, fes 1689310DOI=10.1038/nbt1046
PLC-gamma1 G00002165 P19174 Y775 4 fyn, Src, Pyk2, fes 15592455DOI=10.1038/nbt1046
PLC-gamma1 G00002165 P19174 EGSFESRYQQPFEDF 3 CKI, c-Raf, RSK-2
PLC-gamma1 G00002165 P19174 KLAEGSAYEEVPTSM 2 CKI, TBKI
Plexin 2 G00000113 P70207 S1620 4 Erk2, Erk1, GSK3-beta, p38-alpha 15572359
Plexin 2 G00000113 P70207 S1623 2 CKI, TBKI 15572359
Plexin 2 G00000113 P70207 SFRYTGSPDSLRSRV 1 PKC-zeta
PP1C-A G00000889 P62137 T320 6 CamkII, Erk2, Erk1, PKC-alpha, PKC-delta, PKC-zeta 10506210
PSD-95 G00000004 Q62108 S25 1 Cdk5 14749431
PSD-95 G00000004 Q62108 S290 6 CamkII, Erk2, Erk1, GSK3-beta, Cdk5, p38-alpha 14741046
PSD-95 G00000004 Q62108 S295 2 Erk2, Erk1 15358237DOI=10.1074/mcp.T500041-MCP200
PSD-95 G00000004 Q62108 S35 1 Erk2 14749431
PSD-95 G00000004 Q62108 S415 1 TBKI 15572359
PSD-95 G00000004 Q62108 S418 2 CKI, GSK3-beta 15572359
PSD-95 G00000004 Q62108 T19 2 GSK3-beta, Cdk5 14749431
PSD-95 G00000004 Q62108 T287 4 Erk2, JNK3, p38-alpha, TBKI 14741046
PSD-95 G00000004 Q62108 Y282 2 Pyk2, fes novel
PSD-95 G00000004 Q62108 Y439 1 fyn novel
PSD-95 G00000004 Q62108 DYPTAMTPTSPRRYS 12 Erk2, Erk1, Akt1, Cdk5, PKC-alpha, PKC-delta, PKC-zeta, p70S6K, PKA, Rock-2, RSK-2, TBKI
PSD-95 G00000004 Q62108 LMNSSLGSGTASLRS 2 PKC-zeta, p38-alpha
PTP-1B P35821 S50 3 Erk2, RSK-2, TBKI 10480872
PTP-1B P35821 Y152 1 fes 11106648
PTP-1B P35821 Y153 1 fes 11106648
PTP-1B P35821 Y66 4 fyn, Src, Pyk2, fes 11106648
PTP-1B P35821 S55 3 GSK3-beta, PKC-zeta, TBKI novel
PTP-1B P35821 S70 2 CKI, RSK-2 novel
PTP-1B P35821 Y46 1 fes novel
PTP-1B P35821 ISEDVKSYYTVRQLE 1 Erk2
Pyk2 G00000051 Q9QVP9 Y402 3 fyn, Src, fes 881647511493697DOI=10.1073/pnas.171269898
Rab3effector G00001087 Q9JIR4 S895 5 Erk2, Erk1, Cdk5, JNK3, p38-alpha 15572359
RAC1 G00000231 P63001 S71 1 CKI 10617634
RAC1 G00000231 P63001 YDRLRPLSYPQTDVF 1 fes
RACK1 G00000146 P68040 Y227 4 fyn, Src, Pyk2, fes 12400005
RACK1 G00000146 P68040 T228 1 CKI novel
RAP1A G00000233 P62835 S180 2 PKC-delta, Rock-2 link
RAP1B Q99JI6 S179 6 PKC-alpha, PKC-delta, PKC-zeta, PKA, Rock-2, RSK-2 90343822
RasGap P50904 Y451 4 fyn, Src, Pyk2, fes 1850098
RasGap P50904 TVDGKEIYNTIRRKT 9 CK2, Akt1, Cdk5, PKC-alpha, PKC-delta, PKC-zeta, p70S6K, PKA, Rock-2
Rip11 G00000709 Q8R361 S307 2 p70S6K, RSK-2 15572359
Rip11 G00000709 Q8R361 THKRTYSDEASQLRA 1 CKI
S-adenosylhomocysteine hydrolase-like 1 Q68FL4 SSAASYTDSSDDETS 1 CKI
SAPAP3 Q6PFD5 S58 6 Erk2, Erk1, GSK3-beta, Cdk5, p38-alpha, TBKI 15572359
SAPAP3 Q6PFD5 S64 2 CKI, TBKI novel
SHANK1 G00000862 Q9WV48 T635 6 CKI, GSK3-beta, Akt1, Cdk5, PKC-alpha, PKA 15572359
SHANK1 G00000862 Q9WV48 KRLFRHYTVGSYDSF 12 CamkII, c-Raf, fyn, Src, fes, JNK3, MEK1, PDK-1, PKC-delta, p70S6K, RSK-2, TBKI
SHC G00001391 P29353 S36 2 Erk2, Erk1 11602589
SHC G00001391 P29353 Y349 4 fyn, Src, Pyk2, fes 11075717DOI=10.1038/nbt1046
SHC G00001391 P29353 Y350 4 fyn, Src, Pyk2, fes 9121430DOI=10.1038/nbt1046
SHC G00001391 P29353 TPPEELPSPSASSLGP 2 CKI, TBKI
Src G00000888 P05480 S73 4 Erk2, Erk1, GSK3-beta, p38-alpha 10544291
Stargazin G00000911 O88602 T321 1 GSK3-beta 1180512211805122DOI=10.1074/jbc.M200528200
Stargazin G00000911 O88602 T320 1 GSK3-beta novel
Synapsin1b G00000659 O88935 S551 3 Erk2, Erk1, p38-alpha 8702879
Synapsin1b G00000659 O88935 S62 1 Erk1 8702879
Synapsin1b G00000659 O88935 S67 1 Erk1 8702879
Synapsin1b G00000659 O88935 S9 4 PKC-zeta, p70S6K, PKA, RSK-2 15456851
synGAP G00000009 Q9QUH6 S750 5 c-Raf, PDK-1, PKC-alpha, PKA, TBKI 14970204
synGAP G00000009 Q9QUH6 S751 6 CamkII, CKI, c-Raf, PKC-alpha, PKA, RSK-2 14970204
synGAP G00000009 Q9QUH6 S756 2 CKI, TBKI 14970204
synGAP G00000009 Q9QUH6 S765 1 TBKI 14970204
synGAP G00000009 Q9QUH6 PSITKQHSQTPSTLN 2 CKI, TBKI
Tau G00001036 P10637 S490 2 GSK3-beta, p38-alpha 15572359
Tau G00001036 P10637 S493 3 Erk2, Erk1, Cdk5 15572359
Tau G00001036 P10637 S486 1 GSK3-beta 15572359
Tau G00001036 P10637 T496 2 Erk2, Erk1 15572359
Tau G00001036 P10637 SGYSSPGSPGTPGSR 3 p38-alpha, Rock-2, TBKI
Unc18-1 G00000667 O08599 S142 1 GSK3-beta 15572359
Unc18-1 G00000667 O08599 S146 2 CKI, TBKI 15572359
Unc18-1 G00000667 O08599 Y145 1 fes 15572359
Unc18-1 G00000667 O08599 S149 1 TBKI novel
VAV P27870 Y174 4 fyn, Src, Pyk2, fes DOI=10.1016/S0092-8674(00)00085
Voltage-gated potassium channel beta-2 subunit G00000857 P62482 S20 2 Erk2, GSK3-beta 15572359
Voltage-gated potassium channel beta-2 subunit G00000857 P62482 Y25 4 fyn, Src, Pyk2, fes 15592455
Voltage-gated potassium channel beta-2 subunit G00000857 P62482 LSLRQTGSPGMIYST 3 p70S6K, RSK-2, TBKI

Table 2. Kinases and their substrates

The table is organised so that the substrates and sites for each kinase is reported. The kinase and protein substrate name and identifiers (G2Cdb gene ID and Uniprot accession) are shown. The specific site in that substrate is indicated (e.g. S184) and where a sequence is shown (e.g. FYYEILNSPEKACSL) this indicates that the specific phosphoacceptor residue was not unambiguously defined within that sequence. Links to literature and mouse genetic and human disease data is obtained via the G2Cdb gene link

Kinase G2Cdb gene Substrate Substrate UniProt Site/peptide
Akt1 G00000175 14-3-3 zeta P63101 S58
Akt1 G00000175 Calpain-1 O35350 S379
Akt1 G00000175 Calpain-1 O35350 T380
Akt1 G00000175 DISKS large-associated protein 2 Q8BJ42 S440
Akt1 G00000175 GLUR1 P23818 S710
Akt1 G00000175 GLUR2 P23819 S717
Akt1 G00000175 IRS1 P35569 S24
Akt1 G00000175 IRS1 P35569 S265
Akt1 G00000175 mGlur4a P31423 S859
Akt1 G00000175 mGlur7a Q68ED2 S862
Akt1 G00000175 mKIAA0942 protein Q8CEA6 TISRIGSTTNPFLDI
Akt1 G00000175 NR1 P35438 S889
Akt1 G00000175 NR1 P35438 S890
Akt1 G00000175 PKC-iota Q62074 S254
Akt1 G00000175 PSD-95 Q62108 DYPTAMTPTSPRRYS
Akt1 G00000175 RasGap P50904 TVDGKEIYNTIRRKT
Akt1 G00000175 SHANK1 Q9WV48 T635
CamkII G00000016 14-3-3 zeta P63101 S58
CamkII G00000016 Ankyrin2 Q01484 PKKSDSNASFLRAAR
CamkII G00000016 Ankyrin2 Q01484 S31
CamkII G00000016 Ankyrin2 Q01484 S34
CamkII G00000016 Brain specific p25a Q7TQD2 S19
CamkII G00000016 Calpain-1 O35350 T380
CamkII G00000016 GLUR1 P23818 S849
CamkII G00000016 GLUR2 P23819 S683
CamkII G00000016 IRS1 P35569 S24
CamkII G00000016 mGlur4a P31423 S859
CamkII G00000016 mGlur7a Q68ED2 S862
CamkII G00000016 nNOS Q9Z0J4 S374
CamkII G00000016 nNOS Q9Z0J4 TNRLRSESIAFIEES
CamkII G00000016 NR2B Q01097 S1303
CamkII G00000016 PKC-delta P28867 T50
CamkII G00000016 PP1C-A P62137 T320
CamkII G00000016 PSD-95 Q62108 S290
CamkII G00000016 SHANK1 Q9WV48 KRLFRHYTVGSYDSF
CamkII G00000016 synGAP Q9QUH6 S751
Cdk5 G00000167 14-3-3 zeta P63101 S184
Cdk5 G00000167 Ankyrin2 Q01484 S2439
Cdk5 G00000167 Bassoon O88737 S1418
Cdk5 G00000167 Bassoon O88737 S3217
Cdk5 G00000167 Ca-Activated K Channel-alpha1 Q08460 S711
Cdk5 G00000167 CAMKII-beta P28652 T321
Cdk5 G00000167 cPLA2 P47713 S437
Cdk5 G00000167 DARPP32 Q60829 T34
Cdk5 G00000167 DARPP32 Q60829 T75
Cdk5 G00000167 Drebrin Q9QXS6 S141
Cdk5 G00000167 FAK P34152 S770
Cdk5 G00000167 GLUR2 P23819 NPSSSQNSQNFATYK
Cdk5 G00000167 GLUR2 P23819 S880
Cdk5 G00000167 IRS1 P35569 NLHTDDGYMPMSPGV
Cdk5 G00000167 IRS1 P35569 S24
Cdk5 G00000167 MAP1B P14873 S1775
Cdk5 G00000167 mGlur5 P31424 S1014
Cdk5 G00000167 mGlur5 P31424 S1016
Cdk5 G00000167 NR1 P35438 S889
Cdk5 G00000167 NR2A P35436 S1232
Cdk5 G00000167 Paralemmin Q9Z0P4 S157
Cdk5 G00000167 Paralemmin Q9Z0P4 T141
Cdk5 G00000167 Paralemmin Q9Z0P4 T145
Cdk5 G00000167 PDK-1 Q9Z2A0 S384
Cdk5 G00000167 PKC-delta P28867 EILQGLKYSFSVDWW
Cdk5 G00000167 PSD-95 Q62108 DYPTAMTPTSPRRYS
Cdk5 G00000167 PSD-95 Q62108 S25
Cdk5 G00000167 PSD-95 Q62108 S290
Cdk5 G00000167 PSD-95 Q62108 T19
Cdk5 G00000167 Rab3effector Q9JIR4 S895
Cdk5 G00000167 RasGap P50904 TVDGKEIYNTIRRKT
Cdk5 G00000167 SAPAP3 Q6PFD5 S58
Cdk5 G00000167 SHANK1 Q9WV48 T635
Cdk5 G00000167 Tau P10637 S493
CK2 G00000878 Band 4.1like protein1 Q9Z2H5 S648
CK2 G00000878 Band 4.1like protein1 Q9Z2H5 S650
CK2 G00000878 cAMP-dependent protein kinase type II-alpha regulatory 1.E^E^E^Chain P12367 S75
CK2 G00000878 cAMP-dependent protein kinase type II-alpha regulatory 1.E^E^E^Chain P12367 S77
CK2 G00000878 cPLA2 P47713 S437
CK2 G00000878 GSK3-beta Q9WV60 RGEPNVSYICSRYYR
CK2 G00000878 IRS1 P35569 S99
CK2 G00000878 IRS1 P35569 SSEDLSNYASISFQK
CK2 G00000878 Neuromodulin P06837 AATKIQASFRGHITR
CK2 G00000878 NR2B Q01097 SSNGHVYEKLSSIES
CK2 G00000878 RasGap P50904 TVDGKEIYNTIRRKT
CKI G00000169 14-3-3 zeta P63101 S184
CKI G00000169 14-3-3 zeta P63101 S57
CKI G00000169 14-3-3 zeta P63101 S58
CKI G00000169 Band 4.1like protein1 Q9Z2H5 PELDRDKSDSETEGL
CKI G00000169 Bassoon O88737 S1417
CKI G00000169 Bassoon O88737 S1509
CKI G00000169 b-Catenin Q02248 QSYLDSGIHSGATTT
CKI G00000169 Calmodulin P62204 KDGDGTITTKELGTV
CKI G00000169 Calmodulin P62204 S81
CKI G00000169 Calmodulin P62204 T79
CKI G00000169 cAMP-dependent protein kinase type II-alpha regulatory 1.E^E^E^Chain P12367 S75
CKI G00000169 cPLA2 P47713 LNTSYPLSPLRDFSS
CKI G00000169 cPLA2 P47713 RQNPSRCSVSLSNVE
CKI G00000169 d-Catenin-2 O35927 S531
CKI G00000169 d-Catenin-2 O35927 S534
CKI G00000169 DISKS large-associated protein 2 Q8BJ42 S450
CKI G00000169 eNOS P70313 S1177
CKI G00000169 GLUR2 P23819 NPSSSQNSQNFATYK
CKI G00000169 GLUR2 P23819 S863
CKI G00000169 Guanine nucleotide-binding protein 3 Q8BH66 WGGFSEKSSDWSSEE
CKI G00000169 IRS1 P35569 PRSKSQSSSSCSNPI
CKI G00000169 IRS1 P35569 S105
CKI G00000169 IRS1 P35569 S269
CKI G00000169 IRS1 P35569 SSEDLSNYASISFQK
CKI G00000169 IRS1 P35569 VPNSRGDYMTMQIGC
CKI G00000169 MAP2 P20357 S1799
CKI G00000169 MAP2 P20357 S1800
CKI G00000169 MAP2 P20357 S1801
CKI G00000169 mKIAA0942 protein Q8CEA6 TISRIGSTTNPFLDI
CKI G00000169 nArgbp2 O35413 KAEKRRGSLPDNSIL
CKI G00000169 Neuromodulin P06837 KATTDNSPSSKAED
CKI G00000169 nNOS Q9Z0J4 S1412
CKI G00000169 nNOS Q9Z0J4 S847
CKI G00000169 NR2A P35436 GRCPSDPYKHSLPSQ
CKI G00000169 NR2B Q01097 CKKAGNLYDISEDNS
CKI G00000169 NR2B Q01097 SSNGHVYEKLSSIES
CKI G00000169 Piccolo Q9QYX7 PTAVSLYSPTDEQSV
CKI G00000169 PKC-delta P28867 VQKKPTMYPEWKTTF
CKI G00000169 Plakophilin 4 Q99569 S512
CKI G00000169 PLC-gamma1 P19174 EGSFESRYQQPFEDF
CKI G00000169 PLC-gamma1 P19174 KLAEGSAYEEVPTSM
CKI G00000169 Plexin 2 P70207 S1623
CKI G00000169 PSD-95 Q62108 S418
CKI G00000169 PTP-1B P35821 S70
CKI G00000169 RAC1 P63001 S71
CKI G00000169 RACK1 P68040 T228
CKI G00000169 Rip11 Q8R361 THKRTYSDEASQLRA
CKI G00000169 S-adenosylhomocysteine hydrolase-like 1 Q68FL4 SSAASYTDSSDDETS
CKI G00000169 SAPAP3 Q6PFD5 S64
CKI G00000169 SHANK1 Q9WV48 T635
CKI G00000169 SHC P29353 TPPEELPSPSASSLGP
CKI G00000169 synGAP Q9QUH6 PSITKQHSQTPSTLN
CKI G00000169 synGAP Q9QUH6 S751
CKI G00000169 synGAP Q9QUH6 S756
CKI G00000169 Unc18-1 O08599 S146
c-Raf G00000185 Calpain-1 O35350 S379
c-Raf G00000185 Calpain-1 O35350 T380
c-Raf G00000185 GLUR2 P23819 NPSSSQNSQNFATYK
c-Raf G00000185 IRS1 P35569 S105
c-Raf G00000185 NR1 P35438 S889
c-Raf G00000185 NR1 P35438 S890
c-Raf G00000185 NR2B Q01097 S1303
c-Raf G00000185 PDK-1 Q9Z2A0 S384
c-Raf G00000185 PKC-delta P28867 EILQGLKYSFSVDWW
c-Raf G00000185 PKC-iota Q62074 S114
c-Raf G00000185 PLC-gamma1 P19174 EGSFESRYQQPFEDF
c-Raf G00000185 SHANK1 Q9WV48 KRLFRHYTVGSYDSF
c-Raf G00000185 synGAP Q9QUH6 S750
c-Raf G00000185 synGAP Q9QUH6 S751
Erk1 G00000179 14-3-3 zeta P63101 S57
Erk1 G00000179 Band 4.1like protein1 Q9Z2H5 T475
Erk1 G00000179 Bassoon O88737 KTLQRSLSDPKPLSP
Erk1 G00000179 Bassoon O88737 S3217
Erk1 G00000179 Bassoon O88737 T2904
Erk1 G00000179 Ca-Activated K Channel-alpha1 Q08460 S711
Erk1 G00000179 CAMKII-beta P28652 T321
Erk1 G00000179 Cortactin Q60598 RPPSSPIYEDAAPFK
Erk1 G00000179 cPLA2 P47713 S505
Erk1 G00000179 DARPP32 Q60829 T34
Erk1 G00000179 DISKS large-associated protein 2 Q8BJ42 S450
Erk1 G00000179 Drebrin Q9QXS6 S140
Erk1 G00000179 Drebrin Q9QXS6 S141
Erk1 G00000179 GLUR2 P23819 S880
Erk1 G00000179 IRS1 P35569 S612
Erk1 G00000179 IRS1 P35569 S632
Erk1 G00000179 MAP1B P14873 S1775
Erk1 G00000179 MAP2 P20357 SMDEGDDYLPPTTPA
Erk1 G00000179 mGlur5 P31424 S1014
Erk1 G00000179 mGlur5 P31424 S1016
Erk1 G00000179 NR2A P35436 S1232
Erk1 G00000179 Paralemmin Q9Z0P4 S157
Erk1 G00000179 PKC-delta P28867 EILQGLKYSFSVDWW
Erk1 G00000179 Plexin 2 P70207 S1620
Erk1 G00000179 PP1C-A P62137 T320
Erk1 G00000179 PSD-95 Q62108 DYPTAMTPTSPRRYS
Erk1 G00000179 PSD-95 Q62108 S290
Erk1 G00000179 PSD-95 Q62108 S295
Erk1 G00000179 Rab3effector Q9JIR4 S895
Erk1 G00000179 SAPAP3 Q6PFD5 S58
Erk1 G00000179 SHC P29353 S36
Erk1 G00000179 Src P05480 S73
Erk1 G00000179 Synapsin1b O88935 S551
Erk1 G00000179 Synapsin1b O88935 S62
Erk1 G00000179 Synapsin1b O88935 S67
Erk1 G00000179 Tau P10637 S493
Erk1 G00000179 Tau P10637 T496
Erk2 G00000170 14-3-3 zeta P63101 S184
Erk2 G00000170 14-3-3 zeta P63101 S58
Erk2 G00000170 Adenylate cyclase type IX P51830 S610
Erk2 G00000170 Adenylate cyclase type IX P51830 S613
Erk2 G00000170 Band 4.1like protein1 Q9Z2H5 T475
Erk2 G00000170 Bassoon O88737 S1509
Erk2 G00000170 Bassoon O88737 S3217
Erk2 G00000170 Bassoon O88737 T2904
Erk2 G00000170 b-Catenin Q02248 T653
Erk2 G00000170 Ca-Activated K Channel-alpha1 Q08460 S711
Erk2 G00000170 Calpain-1 O35350 S379
Erk2 G00000170 Calpain-1 O35350 T380
Erk2 G00000170 CAMKII-beta P28652 T321
Erk2 G00000170 Cortactin Q60598 RPPSSPIYEDAAPFK
Erk2 G00000170 cPLA2 P47713 S505
Erk2 G00000170 DARPP32 Q60829 T34
Erk2 G00000170 DISKS large-associated protein 2 Q8BJ42 S450
Erk2 G00000170 Drebrin Q9QXS6 S140
Erk2 G00000170 Drebrin Q9QXS6 S141
Erk2 G00000170 GLUR2 P23819 S880
Erk2 G00000170 IRS1 P35569 S24
Erk2 G00000170 IRS1 P35569 S612
Erk2 G00000170 IRS1 P35569 S632
Erk2 G00000170 IRS1 P35569 S887
Erk2 G00000170 IRS1 P35569 TESITATSPASMVGG
Erk2 G00000170 MAP1B P14873 S1775
Erk2 G00000170 MAP2 P20357 SMDEGDDYLPPTTPA
Erk2 G00000170 mGlur5 P31424 S1014
Erk2 G00000170 mGlur5 P31424 S1016
Erk2 G00000170 nNOS Q9Z0J4 S847
Erk2 G00000170 NR2A P35436 S1232
Erk2 G00000170 Paralemmin Q9Z0P4 S152
Erk2 G00000170 Paralemmin Q9Z0P4 S157
Erk2 G00000170 Paralemmin Q9Z0P4 T145
Erk2 G00000170 PDK-1 Q9Z2A0 S384
Erk2 G00000170 Piccolo Q9QYX7 S4260
Erk2 G00000170 Piccolo Q9QYX7 S4263
Erk2 G00000170 PKC-delta P28867 EILQGLKYSFSVDWW
Erk2 G00000170 PKC-iota Q62074 S114
Erk2 G00000170 Plexin 2 P70207 S1620
Erk2 G00000170 PP1C-A P62137 T320
Erk2 G00000170 PSD-95 Q62108 DYPTAMTPTSPRRYS
Erk2 G00000170 PSD-95 Q62108 S290
Erk2 G00000170 PSD-95 Q62108 S295
Erk2 G00000170 PSD-95 Q62108 S35
Erk2 G00000170 PSD-95 Q62108 T287
Erk2 G00000170 PTP-1B P35821 ISEDVKSYYTVRQLE
Erk2 G00000170 PTP-1B P35821 S50
Erk2 G00000170 Rab3effector Q9JIR4 S895
Erk2 G00000170 SAPAP3 Q6PFD5 S58
Erk2 G00000170 SHC P29353 S36
Erk2 G00000170 Src P05480 S73
Erk2 G00000170 Synapsin1b O88935 S551
Erk2 G00000170 Tau P10637 S493
Erk2 G00000170 Tau P10637 T496
Erk2 G00000170 Voltage-gated potassium channel beta-2 subunit P62482 S20
fes G00000189 14-3-3 zeta P63101 FYYEILNSPEKACSL
fes G00000189 Bassoon O88737 Y1423
fes G00000189 b-Catenin Q02248 Y654
fes G00000189 b-Catenin Q02248 Y86
fes G00000189 Calmodulin P62204 Y138
fes G00000189 Calpain-1 O35350 Y387
fes G00000189 Cortactin Q60598 Y421
fes G00000189 Cortactin Q60598 Y466
fes G00000189 GLUR1 P23818 GMIRVRKSKGKYAYL
fes G00000189 GLUR2 P23819 GVARVRKSKGKYAYL
fes G00000189 GLUR2 P23819 Y869
fes G00000189 GLUR2 P23819 YKEGYNVYGIESVKI
fes G00000189 IRS1 P35569 Y1173
fes G00000189 IRS1 P35569 Y1220
fes G00000189 IRS1 P35569 Y460
fes G00000189 IRS1 P35569 Y891
fes G00000189 IRS1 P35569 Y983
fes G00000189 NR2B Q01097 Y1304
fes G00000189 NR2B Q01097 Y1336
fes G00000189 NR2B Q01097 Y1472
fes G00000189 PDK-1 Q9Z2A0 Y376
fes G00000189 PDK-1 Q9Z2A0 Y379
fes G00000189 PDK-1 Q9Z2A0 Y9
fes G00000189 Pi3K-85 P26450 Y368
fes G00000189 Pi3K-85 P26450 Y607
fes G00000189 Pi3K-85 P26450 Y688
fes G00000189 PKC-delta P28867 Y52
fes G00000189 PKC-delta P28867 Y523
fes G00000189 PKC-iota Q62074 Y116
fes G00000189 PKC-iota Q62074 Y255
fes G00000189 PLC-beta1 Q9Z1B3 Y334
fes G00000189 PLC-gamma1 P19174 Y1253
fes G00000189 PLC-gamma1 P19174 Y771
fes G00000189 PLC-gamma1 P19174 Y775
fes G00000189 PSD-95 Q62108 Y282
fes G00000189 PTP-1B P35821 Y152
fes G00000189 PTP-1B P35821 Y153
fes G00000189 PTP-1B P35821 Y46
fes G00000189 PTP-1B P35821 Y66
fes G00000189 Pyk2 Q9QVP9 Y402
fes G00000189 RAC1 P63001 YDRLRPLSYPQTDVF
fes G00000189 RACK1 P68040 Y227
fes G00000189 RasGap P50904 Y451
fes G00000189 SHANK1 Q9WV48 KRLFRHYTVGSYDSF
fes G00000189 SHC P29353 Y349
fes G00000189 SHC P29353 Y350
fes G00000189 Unc18-1 O08599 Y145
fes G00000189 VAV P27870 Y174
fes G00000189 Voltage-gated potassium channel beta-2 subunit P62482 Y25
fyn G00000186 14-3-3 zeta P63101 FYYEILNSPEKACSL
fyn G00000186 b-Catenin Q02248 Y654
fyn G00000186 b-Catenin Q02248 Y86
fyn G00000186 Calmodulin P62204 Y138
fyn G00000186 Calpain-1 O35350 Y387
fyn G00000186 Cortactin Q60598 Y421
fyn G00000186 GLUR1 P23818 GMIRVRKSKGKYAYL
fyn G00000186 GLUR2 P23819 GVARVRKSKGKYAYL
fyn G00000186 GLUR2 P23819 Y869
fyn G00000186 GLUR2 P23819 YKEGYNVYGIESVKI
fyn G00000186 IRS1 P35569 Y1220
fyn G00000186 IRS1 P35569 Y983
fyn G00000186 NR2B Q01097 Y1304
fyn G00000186 NR2B Q01097 Y1336
fyn G00000186 NR2B Q01097 Y1472
fyn G00000186 PDK-1 Q9Z2A0 Y376
fyn G00000186 PDK-1 Q9Z2A0 Y379
fyn G00000186 Pi3K-85 P26450 Y607
fyn G00000186 Pi3K-85 P26450 Y688
fyn G00000186 PKC-iota Q62074 Y116
fyn G00000186 PKC-iota Q62074 Y270
fyn G00000186 PLC-gamma1 P19174 Y1253
fyn G00000186 PLC-gamma1 P19174 Y771
fyn G00000186 PLC-gamma1 P19174 Y775
fyn G00000186 PSD-95 Q62108 Y439
fyn G00000186 PTP-1B P35821 Y66
fyn G00000186 Pyk2 Q9QVP9 Y402
fyn G00000186 RACK1 P68040 Y227
fyn G00000186 RasGap P50904 Y451
fyn G00000186 SHANK1 Q9WV48 KRLFRHYTVGSYDSF
fyn G00000186 SHC P29353 Y349
fyn G00000186 SHC P29353 Y350
fyn G00000186 VAV P27870 Y174
fyn G00000186 Voltage-gated potassium channel beta-2 subunit P62482 Y25
GSK3-beta G00000171 Adenylate cyclase type IX P51830 S610
GSK3-beta G00000171 Adenylate cyclase type IX P51830 S613
GSK3-beta G00000171 Bassoon O88737 PRATAEFSTQTPSLT
GSK3-beta G00000171 Bassoon O88737 S3217
GSK3-beta G00000171 b-Catenin Q02248 QSYLDSGIHSGATTT
GSK3-beta G00000171 b-Catenin Q02248 S33
GSK3-beta G00000171 Ca-Activated K Channel-alpha1 Q08460 S923
GSK3-beta G00000171 Ca-Activated K Channel-alpha1 Q08460 S924
GSK3-beta G00000171 Calmodulin P62204 T44
GSK3-beta G00000171 cPLA2 P47713 S505
GSK3-beta G00000171 GLUR2 P23819 S880
GSK3-beta G00000171 GLUR4 Q9Z2W8 S862
GSK3-beta G00000171 IRS1 P35569 NLHTDDGYMPMSPGV
GSK3-beta G00000171 IRS1 P35569 S632
GSK3-beta G00000171 IRS1 P35569 S887
GSK3-beta G00000171 MAP2 P20357 SMDEGDDYLPPTTPA
GSK3-beta G00000171 mGlur3 Q9QYS2 S845
GSK3-beta G00000171 Paralemmin Q9Z0P4 S157
GSK3-beta G00000171 Plexin 2 P70207 S1620
GSK3-beta G00000171 PSD-95 Q62108 S290
GSK3-beta G00000171 PSD-95 Q62108 S418
GSK3-beta G00000171 PSD-95 Q62108 T19
GSK3-beta G00000171 PTP-1B P35821 S55
GSK3-beta G00000171 SAPAP3 Q6PFD5 S58
GSK3-beta G00000171 SHANK1 Q9WV48 T635
GSK3-beta G00000171 Src P05480 S73
GSK3-beta G00000171 Stargazin O88602 T320
GSK3-beta G00000171 Stargazin O88602 T321
GSK3-beta G00000171 Tau P10637 S486
GSK3-beta G00000171 Tau P10637 S490
GSK3-beta G00000171 Unc18-1 O08599 S142
GSK3-beta G00000171 Voltage-gated potassium channel beta-2 subunit P62482 S20
JNK3 G00000887 cPLA2 P47713 S505
JNK3 G00000887 DARPP32 Q60829 T34
JNK3 G00000887 Drebrin Q9QXS6 S140
JNK3 G00000887 GSK3-beta Q9WV60 RGEPNVSYICSRYYR
JNK3 G00000887 PKC-delta P28867 EILQGLKYSFSVDWW
JNK3 G00000887 PSD-95 Q62108 T287
JNK3 G00000887 Rab3effector Q9JIR4 S895
JNK3 G00000887 SHANK1 Q9WV48 KRLFRHYTVGSYDSF
MEK1 G00000173 Calpain-1 O35350 S379
MEK1 G00000173 Calpain-1 O35350 T380
MEK1 G00000173 Drebrin Q9QXS6 S140
MEK1 G00000173 Drebrin Q9QXS6 S141
MEK1 G00000173 GLUR1 P23818 GMIRVRKSKGKYAYL
MEK1 G00000173 GLUR2 P23819 GVARVRKSKGKYAYL
MEK1 G00000173 GLUR2 P23819 Y869
MEK1 G00000173 IRS1 P35569 S24
MEK1 G00000173 Neurofascin precursor Q810U3 ETEGNESSEATSPVN
MEK1 G00000173 NR1 P35438 S889
MEK1 G00000173 PKC-delta P28867 VQKKPTMYPEWKTTF
MEK1 G00000173 PKC-iota Q62074 S114
MEK1 G00000173 PKC-iota Q62074 S254
MEK1 G00000173 PKC-iota Q62074 T266
MEK1 G00000173 PKC-iota Q62074 Y255
MEK1 G00000173 SHANK1 Q9WV48 KRLFRHYTVGSYDSF
p38-alpha Band 4.1like protein1 Q9Z2H5 T475
p38-alpha Bassoon O88737 S2865
p38-alpha Bassoon O88737 S3217
p38-alpha Bassoon O88737 T2904
p38-alpha Calmodulin P62204 KDGDGTITTKELGTV
p38-alpha Calpain-1 O35350 S379
p38-alpha Calpain-1 O35350 T380
p38-alpha Cortactin Q60598 RPPSSPIYEDAAPFK
p38-alpha cPLA2 P47713 S505
p38-alpha DARPP32 Q60829 T34
p38-alpha DISKS large-associated protein 2 Q8BJ42 S450
p38-alpha Drebrin Q9QXS6 S140
p38-alpha Drebrin Q9QXS6 S141
p38-alpha GLUR2 P23819 S880
p38-alpha IRS1 P35569 S612
p38-alpha IRS1 P35569 S632
p38-alpha IRS1 P35569 TESITATSPASMVGG
p38-alpha MAP1B P14873 S1775
p38-alpha MAP2 P20357 SMDEGDDYLPPTTPA
p38-alpha mGlur4a P31423 S859
p38-alpha mGlur4a P31423 T865
p38-alpha mGlur5 P31424 S1014
p38-alpha mGlur5 P31424 S1016
p38-alpha mGlur7a Q68ED2 T868
p38-alpha Paralemmin Q9Z0P4 T141
p38-alpha PKC-delta P28867 EILQGLKYSFSVDWW
p38-alpha Plexin 2 P70207 S1620
p38-alpha PSD-95 Q62108 LMNSSLGSGTASLRS
p38-alpha PSD-95 Q62108 S290
p38-alpha PSD-95 Q62108 T287
p38-alpha Rab3effector Q9JIR4 S895
p38-alpha SAPAP3 Q6PFD5 S58
p38-alpha Src P05480 S73
p38-alpha Synapsin1b O88935 S551
p38-alpha Tau P10637 S490
p38-alpha Tau P10637 SGYSSPGSPGTPGSR
p70S6K G00000177 14-3-3 zeta P63101 S58
p70S6K G00000177 Band 4.1like protein1 Q9Z2H5 S466
p70S6K G00000177 Bassoon O88737 S1418
p70S6K G00000177 Bassoon O88737 T1510
p70S6K G00000177 Calpain-1 O35350 S379
p70S6K G00000177 Calpain-1 O35350 T380
p70S6K G00000177 cPLA2 P47713 S726
p70S6K G00000177 Drebrin Q9QXS6 S141
p70S6K G00000177 eNOS P70313 S1177
p70S6K G00000177 eNOS P70313 S613
p70S6K G00000177 eNOS P70313 S631
p70S6K G00000177 GLUR1 P23818 T858
p70S6K G00000177 IRS1 P35569 PRSKSQSSSSCSNPI
p70S6K G00000177 IRS1 P35569 S267
p70S6K G00000177 IRS1 P35569 S302
p70S6K G00000177 IRS1 P35569 SSEDLSNYASISFQK
p70S6K G00000177 MAP2 P20357 S1799
p70S6K G00000177 MAP2 P20357 S1800
p70S6K G00000177 mGlur4a P31423 S859
p70S6K G00000177 mGlur7a Q68ED2 S862
p70S6K G00000177 nNOS Q9Z0J4 SYKVRFNSVSSYSDS
p70S6K G00000177 NR1 P35438 S896
p70S6K G00000177 NR1 P35438 S897
p70S6K G00000177 NR2A P35436 GRCPSDPYKHSLPSQ
p70S6K G00000177 PSD-95 Q62108 DYPTAMTPTSPRRYS
p70S6K G00000177 RasGap P50904 TVDGKEIYNTIRRKT
p70S6K G00000177 Rip11 Q8R361 S307
p70S6K G00000177 SHANK1 Q9WV48 KRLFRHYTVGSYDSF
p70S6K G00000177 Synapsin1b O88935 S9
p70S6K G00000177 Voltage-gated potassium channel beta-2 subunit P62482 LSLRQTGSPGMIYST
PDK-1 G00000184 GLUR1 P23818 S863
PDK-1 G00000184 PKC-delta P28867 T50
PDK-1 G00000184 PKC-delta P28867 VQKKPTMYPEWKTTF
PDK-1 G00000184 SHANK1 Q9WV48 KRLFRHYTVGSYDSF
PDK-1 G00000184 synGAP Q9QUH6 S750
PKA G00001000 14-3-3 zeta P63101 S58
PKA G00001000 Bassoon O88737 S2121
PKA G00001000 Bassoon O88737 S3213
PKA G00001000 b-Catenin Q02248 T653
PKA G00001000 Calpain-1 O35350 GTWRRGSTAGGCRNY
PKA G00001000 Calpain-1 O35350 S379
PKA G00001000 CAMKII-beta P28652 S315
PKA G00001000 cPLA2 P47713 LNTSYPLSPLRDFSS
PKA G00001000 DARPP32 Q60829 T34
PKA G00001000 d-Catenin-2 O35927 S531
PKA G00001000 DISKS large-associated protein 2 Q8BJ42 S440
PKA G00001000 Drebrin Q9QXS6 S140
PKA G00001000 GABA-B R2 O88871 S892
PKA G00001000 IRS1 P35569 S265
PKA G00001000 IRS1 P35569 SSEDLSNYASISFQK
PKA G00001000 MBP P04370 S144
PKA G00001000 mGlur2 P31421 S843
PKA G00001000 mGlur4a P31423 S859
PKA G00001000 mGlur7a Q68ED2 S862
PKA G00001000 mKIAA0942 protein Q8CEA6 S46
PKA G00001000 nArgbp2 O35413 S844
PKA G00001000 NR1 P35438 S897
PKA G00001000 NR2A P35436 GRCPSDPYKHSLPSQ
PKA G00001000 NR2B Q01097 S1303
PKA G00001000 PKC-delta P28867 EILQGLKYSFSVDWW
PKA G00001000 PKC-iota Q62074 S254
PKA G00001000 PSD-95 Q62108 DYPTAMTPTSPRRYS
PKA G00001000 RAP1B Q99JI6 S179
PKA G00001000 RasGap P50904 TVDGKEIYNTIRRKT
PKA G00001000 SHANK1 Q9WV48 T635
PKA G00001000 Synapsin1b O88935 S9
PKA G00001000 synGAP Q9QUH6 S750
PKA G00001000 synGAP Q9QUH6 S751
PKC-alpha G00000159 14-3-3 zeta P63101 S58
PKC-alpha G00000159 Ankyrin2 Q01484 S31
PKC-alpha G00000159 Ankyrin2 Q01484 S34
PKC-alpha G00000159 Calpain-1 O35350 S379
PKC-alpha G00000159 Calpain-1 O35350 T380
PKC-alpha G00000159 DARPP32 Q60829 T34
PKC-alpha G00000159 d-Catenin-2 O35927 S531
PKC-alpha G00000159 DISKS large-associated protein 2 Q8BJ42 S440
PKC-alpha G00000159 Drebrin Q9QXS6 S140
PKC-alpha G00000159 GLUR1 P23818 S710
PKC-alpha G00000159 GLUR2 P23819 S717
PKC-alpha G00000159 Guanine nucleotide-binding protein 3 Q8BH66 WGGFSEKSSDWSSEE
PKC-alpha G00000159 IRS1 P35569 S24
PKC-alpha G00000159 IRS1 P35569 SSEDLSNYASISFQK
PKC-alpha G00000159 MAP2 P20357 S1800
PKC-alpha G00000159 MBP P04370 S144
PKC-alpha G00000159 mGlur4a P31423 S859
PKC-alpha G00000159 mGlur7a Q68ED2 S862
PKC-alpha G00000159 mKIAA0942 protein Q8CEA6 S46
PKC-alpha G00000159 NR1 P35438 S889
PKC-alpha G00000159 NR1 P35438 S890
PKC-alpha G00000159 PKC-delta P28867 EILQGLKYSFSVDWW
PKC-alpha G00000159 PKC-iota Q62074 S254
PKC-alpha G00000159 PP1C-A P62137 T320
PKC-alpha G00000159 PSD-95 Q62108 DYPTAMTPTSPRRYS
PKC-alpha G00000159 RAP1B Q99JI6 S179
PKC-alpha G00000159 RasGap P50904 TVDGKEIYNTIRRKT
PKC-alpha G00000159 SHANK1 Q9WV48 T635
PKC-alpha G00000159 synGAP Q9QUH6 S750
PKC-alpha G00000159 synGAP Q9QUH6 S751
PKC-delta 14-3-3 zeta P63101 S57
PKC-delta 14-3-3 zeta P63101 S58
PKC-delta Ankyrin2 Q01484 S31
PKC-delta Ankyrin2 Q01484 S34
PKC-delta Ca-Activated K Channel-alpha1 Q08460 T709
PKC-delta Calpain-1 O35350 S379
PKC-delta Calpain-1 O35350 T380
PKC-delta DARPP32 Q60829 T34
PKC-delta Drebrin Q9QXS6 S140
PKC-delta GLUR1 P23818 S710
PKC-delta GLUR2 P23819 S717
PKC-delta IRS1 P35569 S24
PKC-delta IRS1 P35569 SSEDLSNYASISFQK
PKC-delta mGlur4a P31423 S859
PKC-delta mGlur7a Q68ED2 S862
PKC-delta NR1 P35438 S889
PKC-delta NR1 P35438 S890
PKC-delta PKC-delta P28867 EILQGLKYSFSVDWW
PKC-delta PKC-iota Q62074 S254
PKC-delta PP1C-A P62137 T320
PKC-delta PSD-95 Q62108 DYPTAMTPTSPRRYS
PKC-delta RAP1A P62835 S180
PKC-delta RAP1B Q99JI6 S179
PKC-delta RasGap P50904 TVDGKEIYNTIRRKT
PKC-delta SHANK1 Q9WV48 KRLFRHYTVGSYDSF
PKC-zeta 14-3-3 zeta P63101 S57
PKC-zeta 14-3-3 zeta P63101 S58
PKC-zeta Ankyrin2 Q01484 S34
PKC-zeta Calpain-1 O35350 S379
PKC-zeta Calpain-1 O35350 T380
PKC-zeta Drebrin Q9QXS6 S140
PKC-zeta GABA-B R2 O88871 S892
PKC-zeta GLUR1 P23818 S710
PKC-zeta GLUR2 P23819 S717
PKC-zeta IRS1 P35569 S24
PKC-zeta IRS1 P35569 SSEDLSNYASISFQK
PKC-zeta mGlur4a P31423 S859
PKC-zeta mGlur7a Q68ED2 S862
PKC-zeta NR1 P35438 S889
PKC-zeta NR1 P35438 S890
PKC-zeta PKC-iota Q62074 S254
PKC-zeta PKC-iota Q62074 T266
PKC-zeta Plexin 2 P70207 SFRYTGSPDSLRSRV
PKC-zeta PP1C-A P62137 T320
PKC-zeta PSD-95 Q62108 DYPTAMTPTSPRRYS
PKC-zeta PSD-95 Q62108 LMNSSLGSGTASLRS
PKC-zeta PTP-1B P35821 S55
PKC-zeta RAP1B Q99JI6 S179
PKC-zeta RasGap P50904 TVDGKEIYNTIRRKT
PKC-zeta Synapsin1b O88935 S9
Pyk2 G00000051 14-3-3 zeta P63101 FYYEILNSPEKACSL
Pyk2 G00000051 Bassoon O88737 Y1423
Pyk2 G00000051 b-Catenin Q02248 Y654
Pyk2 G00000051 b-Catenin Q02248 Y86
Pyk2 G00000051 Calmodulin P62204 Y138
Pyk2 G00000051 Calpain-1 O35350 Y387
Pyk2 G00000051 Cortactin Q60598 Y421
Pyk2 G00000051 GLUR1 P23818 GMIRVRKSKGKYAYL
Pyk2 G00000051 GLUR2 P23819 GVARVRKSKGKYAYL
Pyk2 G00000051 GLUR2 P23819 Y869
Pyk2 G00000051 GLUR2 P23819 YKEGYNVYGIESVKI
Pyk2 G00000051 IRS1 P35569 Y1173
Pyk2 G00000051 IRS1 P35569 Y1220
Pyk2 G00000051 IRS1 P35569 Y983
Pyk2 G00000051 NR2B Q01097 Y1304
Pyk2 G00000051 NR2B Q01097 Y1336
Pyk2 G00000051 NR2B Q01097 Y1472
Pyk2 G00000051 PDK-1 Q9Z2A0 Y376
Pyk2 G00000051 PDK-1 Q9Z2A0 Y379
Pyk2 G00000051 PDK-1 Q9Z2A0 Y9
Pyk2 G00000051 Pi3K-85 P26450 Y607
Pyk2 G00000051 Pi3K-85 P26450 Y688
Pyk2 G00000051 Piccolo Q9QYX7 Y3867
Pyk2 G00000051 PLC-gamma1 P19174 Y1253
Pyk2 G00000051 PLC-gamma1 P19174 Y771
Pyk2 G00000051 PLC-gamma1 P19174 Y775
Pyk2 G00000051 PSD-95 Q62108 Y282
Pyk2 G00000051 PTP-1B P35821 Y66
Pyk2 G00000051 RACK1 P68040 Y227
Pyk2 G00000051 RasGap P50904 Y451
Pyk2 G00000051 SHC P29353 Y349
Pyk2 G00000051 SHC P29353 Y350
Pyk2 G00000051 VAV P27870 Y174
Pyk2 G00000051 Voltage-gated potassium channel beta-2 subunit P62482 Y25
Rock2 G00000163 Calpain-1 O35350 S379
Rock2 G00000163 Calpain-1 O35350 T380
Rock2 G00000163 DARPP32 Q60829 T34
Rock2 G00000163 GLUR2 P23819 S717
Rock2 G00000163 IRS1 P35569 NLHTDDGYMPMSPGV
Rock2 G00000163 IRS1 P35569 S24
Rock2 G00000163 mGlur4a P31423 S859
Rock2 G00000163 mGlur7a Q68ED2 S862
Rock2 G00000163 nNOS Q9Z0J4 S847
Rock2 G00000163 NR1 P35438 S889
Rock2 G00000163 NR1 P35438 S890
Rock2 G00000163 PKC-iota Q62074 T266
Rock2 G00000163 PSD-95 Q62108 DYPTAMTPTSPRRYS
Rock2 G00000163 RAP1A P62835 S180
Rock2 G00000163 RAP1B Q99JI6 S179
Rock2 G00000163 RasGap P50904 TVDGKEIYNTIRRKT
Rock2 G00000163 Tau P10637 SGYSSPGSPGTPGSR
RSK-2 G00000178 14-3-3 zeta P63101 VVGARRSSWRVVSSI
RSK-2 G00000178 Ankyrin2 Q01484 S31
RSK-2 G00000178 Bassoon O88737 S1415
RSK-2 G00000178 Bassoon O88737 S1417
RSK-2 G00000178 Calpain-1 O35350 S379
RSK-2 G00000178 Calpain-1 O35350 T380
RSK-2 G00000178 eNOS P70313 S1177
RSK-2 G00000178 eNOS P70313 S613
RSK-2 G00000178 GLUR2 P23819 S717
RSK-2 G00000178 IRS1 P35569 S265
RSK-2 G00000178 IRS1 P35569 SSEDLSNYASISFQK
RSK-2 G00000178 MAP2 P20357 S1799
RSK-2 G00000178 MAP2 P20357 S1800
RSK-2 G00000178 mKIAA0942 protein Q8CEA6 T48
RSK-2 G00000178 nArgbp2 O35413 S844
RSK-2 G00000178 nNOS Q9Z0J4 SYKVRFNSVSSYSDS
RSK-2 G00000178 NR2A P35436 GRCPSDPYKHSLPSQ
RSK-2 G00000178 NR2B Q01097 S1303
RSK-2 G00000178 PKC-delta P28867 EILQGLKYSFSVDWW
RSK-2 G00000178 PLC-gamma1 P19174 EGSFESRYQQPFEDF
RSK-2 G00000178 PSD-95 Q62108 DYPTAMTPTSPRRYS
RSK-2 G00000178 PTP-1B P35821 S50
RSK-2 G00000178 PTP-1B P35821 S70
RSK-2 G00000178 RAP1B Q99JI6 S179
RSK-2 G00000178 Rip11 Q8R361 S307
RSK-2 G00000178 SHANK1 Q9WV48 KRLFRHYTVGSYDSF
RSK-2 G00000178 Synapsin1b O88935 S9
RSK-2 G00000178 synGAP Q9QUH6 S751
RSK-2 G00000178 Voltage-gated potassium channel beta-2 subunit P62482 LSLRQTGSPGMIYST
Src G00000888 14-3-3 zeta P63101 FYYEILNSPEKACSL
Src G00000888 Bassoon O88737 Y1423
Src G00000888 b-Catenin Q02248 Y654
Src G00000888 b-Catenin Q02248 Y86
Src G00000888 Calmodulin P62204 Y138
Src G00000888 Calpain-1 O35350 Y387
Src G00000888 Cortactin Q60598 Y421
Src G00000888 GLUR1 P23818 GMIRVRKSKGKYAYL
Src G00000888 GLUR2 P23819 GVARVRKSKGKYAYL
Src G00000888 GLUR2 P23819 Y869
Src G00000888 GLUR2 P23819 YKEGYNVYGIESVKI
Src G00000888 IRS1 P35569 Y1220
Src G00000888 IRS1 P35569 Y891
Src G00000888 IRS1 P35569 Y983
Src G00000888 NR2B Q01097 Y1304
Src G00000888 NR2B Q01097 Y1336
Src G00000888 NR2B Q01097 Y1472
Src G00000888 PDK-1 Q9Z2A0 Y376
Src G00000888 PDK-1 Q9Z2A0 Y379
Src G00000888 Pi3K-85 P26450 Y688
Src G00000888 PKC-iota Q62074 Y116
Src G00000888 PKC-iota Q62074 Y270
Src G00000888 PLC-gamma1 P19174 Y1253
Src G00000888 PLC-gamma1 P19174 Y771
Src G00000888 PLC-gamma1 P19174 Y775
Src G00000888 PTP-1B P35821 Y66
Src G00000888 Pyk2 Q9QVP9 Y402
Src G00000888 RACK1 P68040 Y227
Src G00000888 RasGap P50904 Y451
Src G00000888 SHANK1 Q9WV48 KRLFRHYTVGSYDSF
Src G00000888 SHC P29353 Y349
Src G00000888 SHC P29353 Y350
Src G00000888 VAV P27870 Y174
Src G00000888 Voltage-gated potassium channel beta-2 subunit P62482 Y25
TBKI G00000164 14-3-3 zeta P63101 S184
TBKI G00000164 14-3-3 zeta P63101 S58
TBKI G00000164 Adenylate cyclase type IX P51830 RGQGTASPGSVSDLA
TBKI G00000164 Ankyrin2 Q01484 S34
TBKI G00000164 Bassoon O88737 ERSPSTSSTIHSYGQ
TBKI G00000164 Bassoon O88737 PRATAEFSTQTPSLT
TBKI G00000164 Bassoon O88737 S3217
TBKI G00000164 Calpain-m (2) O08529 GALFQDPSFPALPSS
TBKI G00000164 cPLA2 P47713 LNTSYPLSPLRDFSS
TBKI G00000164 d-Catenin-2 O35927 S534
TBKI G00000164 IRS1 P35569 S887
TBKI G00000164 IRS1 P35569 TESITATSPASMVGG
TBKI G00000164 MAP2 P20357 S1161
TBKI G00000164 MAP2 P20357 S1801
TBKI G00000164 mGlur5 P31424 AAARPRSPSPISTLS
TBKI G00000164 mKIAA0942 protein Q8CEA6 TISRIGSTTNPFLDI
TBKI G00000164 nArgbp2 O35413 S844
TBKI G00000164 nArgbp2 O35413 S849
TBKI G00000164 nNOS Q9Z0J4 SYKVRFNSVSSYSDS
TBKI G00000164 NR2B Q01097 SSNGHVYEKLSSIES
TBKI G00000164 NR2B Q01097 T1306
TBKI G00000164 PDK-1 Q9Z2A0 S384
TBKI G00000164 Pi3K-85 P26450 FAEPYNLYSSLKELV
TBKI G00000164 Piccolo Q9QYX7 AQNSEEESPLSPVGQ
TBKI G00000164 PLC-gamma1 P19174 KLAEGSAYEEVPTSM
TBKI G00000164 Plexin 2 P70207 S1623
TBKI G00000164 PSD-95 Q62108 DYPTAMTPTSPRRYS
TBKI G00000164 PSD-95 Q62108 S415
TBKI G00000164 PSD-95 Q62108 T287
TBKI G00000164 PTP-1B P35821 S50
TBKI G00000164 PTP-1B P35821 S55
TBKI G00000164 SAPAP3 Q6PFD5 S58
TBKI G00000164 SAPAP3 Q6PFD5 S64
TBKI G00000164 SHANK1 Q9WV48 KRLFRHYTVGSYDSF
TBKI G00000164 SHC P29353 TPPEELPSPSASSLGP
TBKI G00000164 synGAP Q9QUH6 PSITKQHSQTPSTLN
TBKI G00000164 synGAP Q9QUH6 S750
TBKI G00000164 synGAP Q9QUH6 S756
TBKI G00000164 synGAP Q9QUH6 S765
TBKI G00000164 Tau P10637 SGYSSPGSPGTPGSR
TBKI G00000164 Unc18-1 O08599 S146
TBKI G00000164 Unc18-1 O08599 S149
TBKI G00000164 Voltage-gated potassium channel beta-2 subunit P62482 LSLRQTGSPGMIYST

Table 3. Neurotransmitter receptor modulation of synaptic protein phosphorylation

The table reports the phosphorylation and dephosphorylation that occurs in protein substrates isolated from the postsynaptic density of hippocampus slices stimulated with NMDA (at 3 minutes).

Gene G2Cb gene UniProt Family Sub-family NMDA effect
Ctnnd1 G00000555 P30999 Cell Adhesion Catenins dephosphorylated
Cadm4 Q8R464 Cell Adhesion Other Cell Adhesion Molecules dephosphorylated
Col27a1 Q5QNQ9 Cell Adhesion Other Cell Adhesion Molecules dephosphorylated
Jph1 Q9ET80 Cell Adhesion Other Cell Adhesion Molecules phosphorylated
Pkp2 Q3TIY5 Cell Adhesion Other Cell Adhesion Molecules dephosphorylated
Pkp4 G00000595 Q68FH0 Cell Adhesion Other Cell Adhesion Molecules phosphorylated + dephosphorylated
Aprin Q4VA53 Cell cycle Cell cycle dephosphorylated
Tbrg1 Q3UB74 Cell cycle Cell cycle dephosphorylated
Gria2 G00000058 P23819 Channels and Receptors Glutamate Receptors dephosphorylated
Grm5 G00000064 P31424 Channels and Receptors Glutamate Receptors dephosphorylated
Atp8a1 P70704 Channels and Receptors Other Channels and Receptors phosphorylated
Slc24a2 Q14BI1 Channels and Receptors Other Channels and Receptors phosphorylated
Slc6a17 Q8BJI1 Channels and Receptors Other Channels and Receptors phosphorylated
Chrm5 Q920H4 Channels and Receptors Other ligand receptors phosphorylated
Gabbr1 G00000851 Q9WV18 Channels and Receptors Other ligand receptors dephosphorylated
Cacna1b G00000083 O55017 Channels and Receptors Voltage- and Ligand-gated Ca2+-channel dephosphorylated
Cacna1e G00000078 Q61290 Channels and Receptors Voltage- and Ligand-gated Ca2+-channel dephosphorylated
Cacnb3 G00000079 P54285 Channels and Receptors Voltage- and Ligand-gated Ca2+-channel phosphorylated
Cacnb4 Q8R0S4 Channels and Receptors Voltage- and Ligand-gated Ca2+-channel dephosphorylated
Kcnd2 Q9Z0V2 Channels and Receptors Voltage-gated K+-channel dephosphorylated
Kcnq2 G00000090 Q3UY10 Channels and Receptors Voltage-gated K+-channel phosphorylated
Map1a G00001073 Q9QYR6 Cytoskeletal MAPs phosphorylated + dephosphorylated
Map1b G00000549 P14873 Cytoskeletal MAPs phosphorylated + dephosphorylated
Map2 G00000547 P20357 Cytoskeletal MAPs dephosphorylated
Map4 G00000551 P27546 Cytoskeletal MAPs phosphorylated
Mapt G00001036 P10637 Cytoskeletal MAPs phosphorylated + dephosphorylated
Ablim1 G00000574 Q8K4G5 Cytoskeletal Other Cytoskeletal Proteins dephosphorylated
Add1 G00000569 Q8K232 Cytoskeletal Other Cytoskeletal Proteins phosphorylated
Bsn G00000957 O88737 Cytoskeletal Other Cytoskeletal Proteins phosphorylated + dephosphorylated
Des G00000606 P31001 Cytoskeletal Other Cytoskeletal Proteins dephosphorylated
Epb41l1 G00000593 Q9Z2H5 Cytoskeletal Other Cytoskeletal Proteins dephosphorylated
Epb41l3 G00001827 Q9WV92 Cytoskeletal Other Cytoskeletal Proteins dephosphorylated
Gas2l1 Q8JZP9 Cytoskeletal Other Cytoskeletal Proteins dephosphorylated
Nefh G00000585 P19246 Cytoskeletal Other Cytoskeletal Proteins phosphorylated + dephosphorylated
Nefm G00000567 P08553 Cytoskeletal Other Cytoskeletal Proteins dephosphorylated
P140 G00000666 Q9QWI6 Cytoskeletal Other Cytoskeletal Proteins phosphorylated + dephosphorylated
Palm G00000586 Q9Z0P4 Cytoskeletal Other Cytoskeletal Proteins dephosphorylated
Ppp1r9a G00000197 Q7TN74 Cytoskeletal Other Cytoskeletal Proteins dephosphorylated
Tnks1bp1 P58871 Cytoskeletal Other Cytoskeletal Proteins dephosphorylated
Spnb3 Q68FG2 Cytoskeletal Spectrin phosphorylated
Sptbn1 G00001795 Q62261 Cytoskeletal Spectrin dephosphorylated
Arhgap23 Q69ZH9 G-proteins and Modulators Modulators dephosphorylated
Arhgef2 Q60875 G-proteins and Modulators Modulators phosphorylated
Psd3 G00001270 Q2PFD7 G-proteins and Modulators Modulators dephosphorylated
Syngap1 G00000009 Q9QUH6 G-proteins and Modulators Modulators dephosphorylated
Aak1 G00000881 Q3UHJ0 Kinases Ser/Thr Kinases dephosphorylated
Dclk1 G00000154 Q9JLM8 Kinases Ser/Thr Kinases dephosphorylated
Mark4 Q8CIP4 Kinases Ser/Thr Kinases phosphorylated
Prkcg G00001232 P63318 Kinases Ser/Thr Kinases dephosphorylated
Tnik G00000880 P83510 Kinases Ser/Thr Kinases dephosphorylated
Abi1 G00000596 Q8CBW3 MAGUKs / Adaptors / Scaffolders non-PDZ-domain containg scaffolders dephosphorylated
Begain G00000870 Q68EF6 MAGUKs / Adaptors / Scaffolders non-PDZ-domain containg scaffolders dephosphorylated
Dlgap3 Q6PFD5 MAGUKs / Adaptors / Scaffolders non-PDZ-domain containg scaffolders phosphorylated
Dmxl2 G00000057 Q8BPN8 MAGUKs / Adaptors / Scaffolders non-PDZ-domain containg scaffolders dephosphorylated
Itsn1 G00000777 Q9Z0R4 MAGUKs / Adaptors / Scaffolders non-PDZ-domain containg scaffolders dephosphorylated
Sorbs1 G00000134 Q62417 MAGUKs / Adaptors / Scaffolders non-PDZ-domain containg scaffolders dephosphorylated
Tirap Q99JY1 MAGUKs / Adaptors / Scaffolders non-PDZ-domain containg scaffolders dephosphorylated
CortBP1 G00000572 Q80Z38 MAGUKs / Adaptors / Scaffolders PDZ-domain containing scaffolders dephosphorylated
Dlg4 G00000004 Q62108 MAGUKs / Adaptors / Scaffolders PDZ-domain containing scaffolders dephosphorylated
Lrrc7 G00000019 Q80TE7 MAGUKs / Adaptors / Scaffolders PDZ-domain containing scaffolders dephosphorylated
Pclo G00000864 Q9QYX7 MAGUKs / Adaptors / Scaffolders PDZ-domain containing scaffolders dephosphorylated
Shank3 G00000121 Q4ACU6 MAGUKs / Adaptors / Scaffolders PDZ-domain containing scaffolders dephosphorylated
C20orf30 Q8CIB6 Other transmembrane Other transmembrane dephosphorylated
Cldn11 G00000052 Q60771 Other transmembrane Other transmembrane dephosphorylated
Gja1 G00000626 P23242 Other transmembrane Other transmembrane phosphorylated + dephosphorylated
Kirrel2 Q7TSU7 Other transmembrane Other transmembrane phosphorylated
Syt6 Q9R0N8 Other transmembrane Other transmembrane dephosphorylated
Ppp1r14d Q7TT52 Protein Phosphatases Protein Phosphatases phosphorylated
Ppp1r9b G00000191 Q6R891 Protein Phosphatases Protein Phosphatases dephosphorylated
Dpysl2 G00000441 O08553 Signalling molecules and Enzymes Development dephosphorylated
Gprin1 G00000334 Q3UNH4 Signalling molecules and Enzymes Development dephosphorylated
Bag3 Q9JLV1 Signalling molecules and Enzymes Heat shock / Chaperones / Chaperonins dephosphorylated
Nsun7 Q14AW5 Signalling molecules and Enzymes Other enzymes dephosphorylated
Pde4d G00000290 Q01063 Signalling molecules and Enzymes Other enzymes dephosphorylated
Pin4 Q9CWW6 Signalling molecules and Enzymes Other enzymes phosphorylated
Top2b Q64511 Signalling molecules and Enzymes Other enzymes dephosphorylated
G3bp G00000253 Q3UR88 Signalling molecules and Enzymes Other signalling molecules dephosphorylated
Kcnip2 Q3YAB1 Signalling molecules and Enzymes Other signalling molecules phosphorylated
Marcksl1 P28667 Signalling molecules and Enzymes Other signalling molecules dephosphorylated
Plcb1 G00000355 Q9Z1B3 Signalling molecules and Enzymes Other signalling molecules dephosphorylated
Ppfia3 G00001017 P60469 Signalling molecules and Enzymes Other signalling molecules phosphorylated + dephosphorylated
Sipa1l1 G00000020 Q8C0T5 Signalling molecules and Enzymes Other signalling molecules dephosphorylated
Myo18a G00000756 Q9JMH9 Synaptic Vesicles / Protein Transport Motor Proteins dephosphorylated
Rims1 G00001087 Q99NE5-7 Synaptic Vesicles / Protein Transport Synaptic vesicle dephosphorylated
Rpl14 G00001259 Q9CR57 Transcription and Translation Ribosomal Proteins phosphorylated
Bat2 Q7TSC1 Transcription and Translation Splicing dephosphorylated
Hnrpa1 P49312 Transcription and Translation Splicing dephosphorylated
Hnrpk P61979 Transcription and Translation Splicing phosphorylated
Sfrs10 P62996 Transcription and Translation Splicing dephosphorylated
Sfrs7 Q8BL97 Transcription and Translation Splicing dephosphorylated
Srrm1 Q52KI8 Transcription and Translation Splicing dephosphorylated
Srrm2 Q8BTI8 Transcription and Translation Splicing dephosphorylated
Tra2a Q6PFR5 Transcription and Translation Splicing dephosphorylated
Cbx3 P23198 Transcription and Translation Transcription dephosphorylated
Mll P55200 Transcription and Translation Transcription dephosphorylated
Pparbp Q925J9 Transcription and Translation Transcription dephosphorylated
Purb G00000951 O35295 Transcription and Translation Transcription dephosphorylated
Smarcc2 Q6PDG5 Transcription and Translation Transcription dephosphorylated
Son Q9QX47 Transcription and Translation Transcription dephosphorylated
Zkscan17 Q5SXI5 Transcription and Translation Transcription phosphorylated
Eif3s9 Q8JZQ9 Transcription and Translation Translation phosphorylated
... ... Uncharacterised / novel Uncharacterised / novel dephosphorylated
2700049A03Rik Q8C9T9 Uncharacterised / novel Uncharacterised / novel dephosphorylated
4932438A13Rik Q05BP8 Uncharacterised / novel Uncharacterised / novel dephosphorylated
4933411K20Rik Q9D462 Uncharacterised / novel Uncharacterised / novel dephosphorylated
Bcas1 G00000821 Q8C0B4 Uncharacterised / novel Uncharacterised / novel phosphorylated
C2orf33 homolog Q6PCP5 Uncharacterised / novel Uncharacterised / novel dephosphorylated
Col20a1 Q923P0 Uncharacterised / novel Uncharacterised / novel dephosphorylated
Dnajc6 G00000282 Q80TZ3 Uncharacterised / novel Uncharacterised / novel dephosphorylated
Efcab5 Q5NC53 Uncharacterised / novel Uncharacterised / novel phosphorylated
Farp1 Q3UY58 Uncharacterised / novel Uncharacterised / novel dephosphorylated
Gm1568 Q3UHB8 Uncharacterised / novel Uncharacterised / novel phosphorylated + dephosphorylated
Gm879 Q5SSH6 Uncharacterised / novel Uncharacterised / novel dephosphorylated
Hd G00001247 P42859 Uncharacterised / novel Uncharacterised / novel dephosphorylated
Hdgfrp2 Q99L92 Uncharacterised / novel Uncharacterised / novel dephosphorylated
Hisppd2a Q7TSP1 Uncharacterised / novel Uncharacterised / novel dephosphorylated
Kbtbd11 Q8BNW9 Uncharacterised / novel Uncharacterised / novel dephosphorylated
Kctd16 Q5DTY9 Uncharacterised / novel Uncharacterised / novel phosphorylated
KIAA0773 homolog Q3TY60 Uncharacterised / novel Uncharacterised / novel dephosphorylated
mg638 Q9ER87 Uncharacterised / novel Uncharacterised / novel dephosphorylated
Ndrg2 Q9CTJ5 Uncharacterised / novel Uncharacterised / novel dephosphorylated
Nucks1 Q80XU3 Uncharacterised / novel Uncharacterised / novel dephosphorylated
Odf2 A3KGV1 Uncharacterised / novel Uncharacterised / novel phosphorylated
Sgip1 G00000827 Q8VD37 Uncharacterised / novel Uncharacterised / novel dephosphorylated
unnamed protein product BAC39111 Uncharacterised / novel Uncharacterised / novel dephosphorylated
Wapal Q65Z40 Uncharacterised / novel Uncharacterised / novel dephosphorylated
Wdr20a Q8R0J5 Uncharacterised / novel Uncharacterised / novel phosphorylated
© G2C 2014. The Genes to Cognition Programme received funding from The Wellcome Trust and the EU FP7 Framework Programmes:
EUROSPIN (FP7-HEALTH-241498), SynSys (FP7-HEALTH-242167) and GENCODYS (FP7-HEALTH-241995).

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