G2C::PSD-95 SH3 domain peptide interactors
SH3 domain of PSD-95 mediates inflammatory pain through PI3 kinase recruitment
Margaret I. Arbuckle1*, Noboru H. Komiyama2*, Ada Delaney1*, Marcelo Coba2, Emer M. Garry1, Roberta Rosie1, Andrew Allchorne1, Lynsey H. Forsyth1, Matthew Bence1, Holly J. Carlisle3, Thomas J. O'Dell3, Rory Mitchell1, Susan M. Fleetwood-Walker1† and Seth G.N. Grant2†
Author email: sg3@sanger.ac.uk * - These authors contributed equally to this work; † - These authors supervised the project
- Centre for Neuroregeneration, The University of Edinburgh, Institute of Immunology and Infection, Ashworth Buildings, Kings Buildings, Edinburgh EH9 3JT, UK
- The Wellcome Trust Sanger Institute, Genome Campus, Genes to Cognition Programme, Hinxton, Cambridgeshire CB10 1SA, UK
- Department of Physiology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, California 90024, USA

Mutation of the tryptophan 470 residue of PSD-95 to leucine in the polyproline binding site of the SH3 domain blocks interaction with PI3 kinase (Pik3c2α) and inflammatory pain.
Sensitisation to inflammatory pain is a pathological form of neuronal plasticity that is poorly understood and treated. Here we examine the role of the SH3 domain of PSD-95 using mice carrying a single amino acid substitution in the polyproline binding site. Testing multiple forms of plasticity we found sensitisation to inflammation was specifically attenuated. The inflammatory response required recruitment of phosphoinositide 3-kinase-C2α to the SH3 binding site of PSD-95. In wild-type mice, wortmannin or peptide competition attenuated the sensitisation. These results show different types of behavioural plasticity are mediated by specific domains of PSD-95 and suggest novel therapeutic avenues for inflammatory pain.
Supplementary Table 1.
List of 290 peptide sequences binding the SH3 domain of PSD-95, on Jerini SH3-domain profilertm. Shown are Gene Symbol, HGNC ID, Peptide Sequence, mean intensity of triplicates (Mean Intensity), standard deviation (SD), and UniProt Acc.
Gene Symbol | HGNC ID | Peptide Sequence | Mean Intensity | SD | UniProt Acc |
---|---|---|---|---|---|
PRKAR1B | HGNC:9390 | HLCISKPERPMKFLR | 19538 | 1211 | P31321 |
RAPGEF2 | HGNC:16854 | GRYREPPPTPPGYIG | 18732 | 1674 | Q9Y4G8 |
PIK3C2A | HGNC:8971 | FPLWKLPGFPNRMVL | 17789 | 1833 | O00443 |
ABL2 | HGNC:77 | MKKRNAPTPPKRSSS | 17221 | 1422 | P42684 |
RALGPS1 | HGNC:16851 | RSLKMVPSIPYLGIYG | 14320 | 869 | Q5JS13 |
GAB1 | HGNC:4066 | MGFRSSPKTPPRRPV | 14191 | 1733 | Q13480 |
HEATR1 | HGNC:25517 | MLSLNHPLAPVRILA | 11688 | 212 | Q9H583 |
ZNF200 | HGNC:12993 | MAAKVVPMPPKPKQS | 10905 | 563 | P98182 |
FMOD | HGNC:3774 | RNLKYLPFVPSRMKY | 10563 | 906 | Q06828 |
ENPP2 | HGNC:3357 | HSPYMRPVYPTKTFP | 10202 | 452 | Q13822 |
XPO5 | HGNC:17675 | PDYRLRPMLPRVFVK | 9898 | 677 | Q9HAV4 |
IGSF22 | HGNC:26750 | MLKKRAPPAPKKKQK | 9651 | 988 | Q8N9C0 |
RC3H1 | HGNC:29434 | MNKRLVPRRPLSASL | 9437 | 767 | Q5TC82 |
COQ10A | HGNC:26515 | PPPGPPPPPRPMRFL | 9420 | 665 | Q96MF6 |
CDKL5 | HGNC:11411 | PKKPHTPCVPNRALH | 9222 | 1755 | O76039 |
HDAC2 | HGNC:4853 | ENLRMLPHAPGVQMQ | 9219 | 953 | Q92769 |
GABBR2 | HGNC:4507 | GWARGAPRPPPSSPP | 9002 | 1290 | O75899 |
SOS1 | HGNC:11187 | GTRRHLPSPPLTQEV | 8977 | 909 | Q07889 |
RGS9 | HGNC:10004 | SWPRSRPRAPPKARM | 7001 | 781 | O75916 |
SCN2A | HGNC:10588 | RASRVLPILPMNGKM | 8711 | 773 | Q99250 |
RIMS2 | HGNC:17283 | RTTNHSPPTPRRSPL | 8619 | 975 | Q9UQ26 |
ROBO2 | HGNC:10250 | GRMDQQPALPHRREG | 8914 | 351 | Q9HCK4 |
ADCY3 | HGNC:234 | NGTDRLPLVPSKYSM | 8611 | 896 | O60266 |
ROBO2 | HGNC:10250 | YDLSDLPGPPSKPQV | 8594 | 675 | Q9HCK4 |
CHERP | HGNC:16930 | RHPFERPPYPHRFDY | 8501 | 811 | Q8IWX8 |
MNT | HGNC:7188 | SPQPLPPPPPLPAAA | 8433 | 1109 | Q99583 |
MED12L | HGNC:16050 | YHTHPMPKPRSYYLQ | 8424 | 906 | Q86YW9 |
SRCAP | HGNC:16974 | LSLKPTPPAPVRLSP | 8401 | 422 | Q6ZRS2 |
UBTF | HGNC:12511 | KKLKKHPDFPKKPLT | 8391 | 688 | P17480 |
SYTL3 | HGNC:15587 | RAKLVLPSRPRKLQE | 8307 | 557 | Q4VX76 |
CLCNKB | HGNC:2027 | VIVKKLPYLPRILGR | 8001 | 1209 | P51801 |
SOS2 | HGNC:11188 | EEPLIPPPLPPRKKF | 7985 | 320 | Q07890 |
AJAP1 | HGNC:30801 | LLPRSPPRPPRLWSF | 7965 | 870 | Q9UKB5 |
EIF2S1 | HGNC:3265 | IKINLIAPPRYVMTT | 7909 | 888 | P05198 |
TMEM54 | HGNC:24143 | VLSRYLPSTPLRWTV | 7834 | 557 | Q969K7 |
NFE2 | HGNC:7780 | DSGFPLPPPPYELPA | 7815 | 412 | Q16621 |
CBLB | HGNC:1542 | IPHLSLPPVPPRLDL | 7803 | 908 | Q13191 |
MBTPS1 | HGNC:15456 | DTSVRRPTTPIKPPP | 7800 | 677 | Q14703 |
PTBP1 | HGNC:9583 | YGNSPLHRFKKPGSK | 7795 | 768 | P26599 |
RSF1 | HGNC:18118 | RRLRRHPSRPMRQSR | 7765 | 1754 | Q96T23 |
CACHD1 | HGNC:29314 | CIVVIQPEIPVKQLK | 7732 | 980 | Q5VU97 |
PGR | HGNC:8910 | DFPLGPPPPLPPRAT | 7703 | 869 | Q8NG45 |
PNMA2 | HGNC:9159 | LPHKTPPRIPPKPKS | 7699 | 1433 | Q9UL42 |
CNGB1 | HGNC:2151 | RVLPQPPGTPRKTKM | 7678 | 566 | Q14028 |
FCHSD1 | HGNC:25463 | PRLRPMRPPPPPPAK | 7674 | 1001 | Q86WN1 |
PIK3AP1 | HGNC:30034 | SIRKGPPVRPWRDRP | 7666 | 893 | Q6ZUJ8 |
RAP1GAP | HGNC:9858 | LRPAVPPGRPRRGSL | 7655 | 343 | Q9UQ51 |
MAOB | HGNC:6834 | FLERHLPSVPGLLRL | 7641 | 540 | P27338 |
PRAMEF4 | HGNC:31971 | WPFRRLPLRPLIKMP | 7509 | 444 | O60810 |
PCDH15 | HGNC:14674 | ISPPSPPPAPAPLAP | 7321 | 905 | Q96QU1 |
PAX7 | HGNC:8621 | PRMMRPAPGQNYPRT | 7289 | 311 | P23759 |
PRELP | HGNC:9357 | DLPPPLPPGPPSIFP | 7192 | 955 | P51888 |
FOLH1 | HGNC:3788 | TSLFEPPPPGYENVS | 6993 | 349 | Q04609 |
NOXA1 | HGNC:10668 | HLFSGVPAPPARLCF | 6980 | 875 | Q86UR1 |
HCLS1 | HGNC:4844 | SREHPVPLLPIRQTL | 6945 | 1542 | P14317 |
PIKFYVE | HGNC:23785 | EKSKELPFTPLGWHH | 6907 | 690 | Q9Y2I7 |
SNX8 | HGNC:14972 | FPYRMVPALPPKRML | 6854 | 908 | Q9Y5X2 |
TYRO3 | HGNC:12446 | PPLPLPPPPRLGLLL | 6878 | 777 | Q06418 |
TOMM40 | HGNC:18001 | ALVGLPPPPPSPPGF | 6803 | 675 | O96008 |
PTPN1 | HGNC:9642 | PPEHIPPPPRPPKRI | 6798 | 1110 | P18031 |
STRADB | HGNC:13205 | DSILSLLPPAYNKPS | 6755 | 955 | Q9C0K7 |
STAP2 | HGNC:30430 | PAKLPKPPVGPKPEP | 6604 | 871 | Q9UGK3 |
BCL9L | HGNC:23688 | SQPPPLPPPPPPAPG | 6590 | 992 | Q86UU0 |
KLF4 | HGNC:6348 | HMKRLPPVLPGRPYD | 6540 | 733 | O43474 |
EIF4E2 | HGNC:3293 | PPPPPPLPPPGPPPR | 6538 | 340 | O60573 |
MARCH10 | HGNC:26655 | QAPMVLLRKRKPNLR | 6442 | 598 | Q8NA82 |
TTYH2 | HGNC:13877 | LIGRASPPPTYSPSM | 6411 | 420 | Q9BSA4 |
POU3F3 | HGNC:9216 | PQPPPPPPQGPDVKG | 6407 | 802 | P20264 |
ZIC5 | HGNC:20322 | PAPPLPPTPSPPPPP | 6397 | 567 | Q96T25 |
COBRA1 | HGNC:24324 | CVMKHLPKVPEKKLK | 6378 | 332 | Q8WX92 |
ATXN2 | HGNC:10555 | PYPSAAPPPPGPGPP | 6215 | 675 | Q99700 |
C20orf160 | HGNC:16153 | CSRIMAPRTPLKHVT | 6001 | 1233 | Q5JYR8 |
SUV420H2 | HGNC:28405 | DLRRLAPAPPATPAP | 5990 | 896 | Q86Y97 |
CDK7 | HGNC:1778 | ELLLRVPFLPGDSDL | 5983 | 2128 | P50613 |
ENPP1 | HGNC:3356 | YTKNMRPVYPTKTFP | 5978 | 443 | P22413 |
IDS | HGNC:5389 | AVGYHKPHIPFRYPK | 5903 | 167 | P22304 |
USP42 | HGNC:20068 | SSTKKAPPPRDPGTP | 5806 | 776 | Q9H9J4 |
HUNK | HGNC:13326 | MEFIPVPPPRTPRIV | 5722 | 1090 | P57058 |
GAS2L2 | HGNC:24846 | SDRRLRPPTPSSPRP | 5719 | 678 | Q8NHY3 |
MYCBPAP | HGNC:19677 | KEEKRPPWAPPPQHN | 5567 | 888 | Q8TBZ2 |
EPB41L3 | HGNC:3380 | FFRLLLPEAPPKKFL | 5510 | 609 | Q9Y2J2 |
ZMYM3 | HGNC:13054 | APTPPPPPPPATPRK | 5438 | 785 | Q14202 |
KIFC2 | HGNC:29530 | PPGRLLPSAPTLRSP | 5219 | 459 | Q96AC6 |
PCDHA13 | HGNC:8667 | VTCTLTPHVPFKLVS | 5211 | 436 | Q9Y5I0 |
KRBA1 | HGNC:22228 | TARRARPLPPDAPPA | 5206 | 1126 | A5PL33 |
PTPN1 | HGNC:9642 | EPPPEHIPPPPRPPK | 4906 | 670 | P18031 |
BEST4 | HGNC:17106 | GRVRGTPRPPHLLRF | 4901 | 905 | Q8NFU0 |
PRC1 | HGNC:9341 | MLYGSAPRTPSKRRG | 4877 | 987 | O43663 |
RIN1 | HGNC:18749 | LSPPAVPPPPVPVLP | 4841 | 457 | Q13671 |
GTF3C1 | HGNC:4664 | SWMRYIPPIPVHRDF | 4825 | 834 | Q12789 |
PHF8 | HGNC:20672 | PKARVTPTLPKQDRP | 4793 | 732 | Q9UPP1 |
BCL9L | HGNC:23688 | GTPQSQPPPLPPPPP | 4767 | 921 | Q86UU0 |
DENND2A | HGNC:22212 | SLPPPPLPSSPPPSS | 4745 | 764 | Q9ULE3 |
DIDO1 | HGNC:2680 | LFSGQHGPPPYGDSR | 4733 | 399 | Q9BTC0 |
PCLO | HGNC:13406 | SAQPPPPPPPPPPPP | 4691 | 409 | Q9Y6V0 |
ARAP2 | HGNC:16924 | LRHRPVPEIPGSTKG | 4690 | 387 | Q8WZ64 |
GIT2 | HGNC:4273 | RHLKHTPWPPTLLQM | 4572 | 382 | Q14161 |
NKX2-2 | HGNC:7835 | MEVTPLPSPRRVAVP | 4568 | 1001 | O95096 |
RUNX3 | HGNC:10473 | RFHHTYLPPPYPGAP | 4500 | 785 | Q13761 |
CSMD2 | HGNC:19290 | LMCKPPPLIPNGKVV | 4459 | 433 | Q7Z408 |
KLF8 | HGNC:6351 | ASMLQAPIRPPKPQS | 4431 | 233 | O95600 |
NCKAP5 | HGNC:29847 | PNFRTAPGMPSRRDW | 4428 | 902 | O14513 |
DIAPH3 | HGNC:15480 | PSGGGVPPPPPPPPP | 4410 | 855 | Q9NSV4 |
POLG | HGNC:9179 | LKAMVQAPPGYTLVG | 4326 | 299 | P54098 |
CEBPD | HGNC:1835 | QFFKQLPSPPFLPAA | 4312 | 346 | P49716 |
NFATC4 | HGNC:7778 | SFPLGLPFSPPAPFR | 4308 | 455 | Q14934 |
RARA | HGNC:9864 | YVRKRRPSRPHMFPK | 4299 | 448 | P10276 |
PPP2R5D | HGNC:9312 | PMFRAPPPLPPVYSM | 4297 | 607 | Q14738 |
SNTB2 | HGNC:11169 | GLGPPSPPAPPRGPA | 4205 | 690 | Q13425 |
CNTN3 | HGNC:2173 | LDCKPRASPRALSSW | 4193 | 577 | Q9P232 |
FKSG66 | NKMKSLPCLPLPTQT | 4150 | 485 | Q9BZ58 | |
RNPS1 | HGNC:10080 | PPRRMLPPPPMWLRS | 4147 | 422 | Q15287 |
CIDEA | HGNC:1976 | FTPLMHPARPFRVSN | 4094 | 753 | O60543 |
SF3B2 | HGNC:10769 | ITLRLPPGFPVKIEI | 4037 | 685 | Q13435 |
SUSD2 | HGNC:30667 | PPFRTPPRVPSMSHW | 4025 | 431 | Q9UGT4 |
NTNG2 | HGNC:14288 | MRLLRPALGGTYVQR | 4001 | 509 | Q96CW9 |
NEU4 | HGNC:21328 | WLSMGVPRTPSRTVL | 3922 | 555 | Q8WWR8 |
FGD5 | HGNC:19117 | MFRGPKPPIAPKPRL | 3539 | 424 | Q6ZNL6 |
CDH4 | HGNC:1763 | RPVGPEPQYPIRPMV | 3527 | 230 | P55283 |
BMPR1B | HGNC:1077 | CIKKLRPSFPNRWSS | 3512 | 332 | O00238 |
AP3B2 | HGNC:567 | PDHRLLLRNTKPLLQ | 3503 | 533 | Q13367 |
ZBTB40 | HGNC:29045 | HGAGGEPDAPKKKKK | 3488 | 223 | Q9NUA8 |
B4GALT1 | HGNC:924 | TGGARPPPPLGASSQ | 3476 | 356 | P15291 |
FLNB | HGNC:3755 | PKAKLKPGAPLKPKL | 3459 | 886 | O75369 |
CTAGE5 | HGNC:7057 | PGFVPPPLAPVRGPL | 3433 | 468 | O15320 |
DERL2 | HGNC:17943 | LLNFQAPFLPWVLMG | 3429 | 964 | Q9GZP9 |
FAM40A | HGNC:25916 | NKQPQPPPPPPPAAA | 3416 | 760 | Q5VSL9 |
MARCH9 | HGNC:25139 | SPPPRPLPWPWPPTP | 3400 | 774 | Q86YJ5 |
AGBL5 | HGNC:26147 | PFVRTLPTRPRWERI | 3384 | 524 | Q8NDL9 |
PHF20 | HGNC:16098 | LQSREHPDLPLWCQP | 3377 | 780 | Q9BVI0 |
ANKRD24 | HGNC:29424 | PKKRKAPPPPASIPM | 3301 | 640 | Q8TF21 |
TAF1L | HGNC:18056 | KLMPPPPPPPGPMKK | 3294 | 965 | Q8IZX4 |
PYGO1 | HGNC:30256 | STFRMPPHVPPRMSS | 3105 | 704 | Q9Y3Y4 |
DMRT1 | HGNC:2934 | RMHSYYPPPSYLGQS | 2996 | 450 | Q9Y5R6 |
C9orf79 | HGNC:26672 | SGQRIPPPAPRPSVE | 2994 | 350 | Q6ZUB1 |
ZFR | HGNC:17277 | LKPKQPPKPPQIHYC | 2990 | 422 | Q96KR1 |
ZNF207 | HGNC:12998 | GMPPPVPRPGIPPMT | 2986 | 290 | O43670 |
XPO5 | HGNC:17675 | PDYRLRPMLPRVFVK | 2985 | 244 | Q9HAV4 |
CLN5 | HGNC:2076 | FYYPFKPHLPTKEFL | 2985 | 614 | O75503 |
NFATC4 | HGNC:7778 | LGLPFSPPAPFRPPP | 2981 | 603 | Q14934 |
WFDC3 | HGNC:15957 | GRFCVPPVLPPKLTM | 2970 | 807 | Q8IUB2 |
TNIK | HGNC:30765 | QEEDIPPKVPQRTTS | 2966 | 266 | Q9UKE5 |
ZDHHC12 | HGNC:19159 | QTAMVPPAIPLRRCR | 2963 | 340 | Q96GR4 |
TCERG1 | HGNC:15630 | RGPPPLMRPPPPFGM | 2962 | 562 | Q8CGF7 |
C1orf52 | HGNC:24871 | TTEKKPPPPELDMAI | 2958 | 299 | Q8N6N3 |
QPCTL | HGNC:25952 | ERGLMEPLLPPKRRL | 2955 | 394 | Q9NXS2 |
NMB | HGNC:7842 | VSLSRPAPQIQYRRL | 2951 | 412 | P08949 |
DIAPH2 | HGNC:2877 | GGAPLPPPPPPLPGM | 2946 | 611 | O60879 |
PPP1R15A | HGNC:14375 | ARLRNPPLAPIPALT | 2944 | 780 | O75807 |
GAB3 | HGNC:17515 | IMSNTPPPRPPKPSH | 2939 | 422 | Q8WWW8 |
SAP25 | SPCPSSPQPPSRSPS | 2935 | 257 | Q8TEE9 | |
PTGS1 | HGNC:9604 | YYTRILPSVPKDCPT | 2931 | 233 | P23219 |
AFARP1 | MGRRSHPRLPGARPH | 2928 | 317 | Q8NHP2 | |
SYNPO2L | HGNC:23532 | GLSPAPPPFLSSQGP | 2917 | 654 | Q9H987 |
DUX3 | HGNC:3081 | PSVKFRPGLPAMALL | 2901 | 231 | Q96PT4 |
DQX1 | HGNC:20410 | FLELEAPPLPQPRVC | 2883 | 344 | Q8TE96 |
PCDHGA7 | HGNC:8705 | SFRKITPKLPKMFHL | 2874 | 183 | Q9Y5G6 |
SPATA16 | HGNC:29935 | LITMPLPHIPLKNIM | 2833 | 342 | Q9BXB7 |
PDX1 | HGNC:6107 | LLALPPPPPPGGAVP | 2825 | 383 | P52945 |
CDK11A | HGNC:1730 | HWSRSPPRPPRERFE | 2819 | 403 | Q9UQ88 |
MASP2 | HGNC:6902 | RRWTLTAPPGYRLRL | 2813 | 310 | O00187 |
SNX24 | HGNC:21533 | KKCIKTPEIPSKHVR | 2810 | 332 | Q9Y343 |
ZCCHC7 | HGNC:26209 | YHLTTKPGPPKKPKT | 2808 | 175 | Q8N3Z6 |
TBX3 | HGNC:11602 | TSMAYHPFLPHRAPD | 2796 | 123 | O15119 |
ZNF207 | HGNC:12998 | GMPPGMPPPVPRPGI | 2792 | 512 | O43670 |
HGD | HGNC:4892 | WHLRGLPMAPWHLCL | 2791 | 301 | Q93099 |
KLHDC8B | HGNC:28557 | RTWTRHPSLPSRRAF | 2783 | 189 | Q8IXV7 |
ZNF217 | HGNC:13009 | TKLKPLPVAPSQPTL | 2780 | 222 | O75362 |
GALNT7 | HGNC:4129 | EGWQGNPPPIYVGSS | 2777 | 674 | Q86SF2 |
USP21 | HGNC:12620 | PMLRPLPPRPGLPDE | 2768 | 443 | Q9UK80 |
ZMIZ1 | HGNC:16493 | LGPGPSPYPLPPPPG | 2761 | 232 | Q9ULJ6 |
IRF7 | HGNC:6122 | MALAPERAAPRVLFG | 2754 | 446 | Q92985 |
SNX22 | HGNC:16315 | KKLYKVPDFPSKRLP | 2752 | 657 | Q96L94 |
SIM2 | HGNC:10883 | SPAKNPPEPPANTAR | 2749 | 305 | Q14190 |
CDK17 | HGNC:8750 | HRRKVLHRDLKPQNL | 2744 | 504 | Q00537 |
ITM2C | HGNC:6175 | KPLLQERPPAYNLEA | 2739 | 296 | Q9NQX7 |
ENPP3 | HGNC:3358 | FKPYLTPDLPKRLHY | 2727 | 701 | O14638 |
SNRPN | HGNC:11164 | PPGPGAPPPPVGRAA | 2726 | 433 | P63162 |
SHANK1 | HGNC:15474 | SEGGGAPQPPPRPPS | 2719 | 454 | Q9Y566 |
TIE1 | HGNC:11809 | RIVRTPPGPPLRLAR | 2715 | 510 | P35590 |
RTF1 | HGNC:28996 | KERFRKAPPNYAMKK | 2700 | 539 | Q92541 |
DENND2A | HGNC:22212 | KEKRNLPPLPSLPPP | 2653 | 416 | Q9ULE3 |
NSUN4 | HGNC:31802 | DISRFPPARPGSLGV | 2648 | 197 | Q96CB9 |
ADCK5 | HGNC:21738 | FHSALLHRRQKPWPS | 2633 | 511 | Q3MIX3 |
GUCY2F | HGNC:4691 | INRLKKPPPVYRPVV | 2616 | 211 | P51841 |
ESX1 | HGNC:14865 | PGSRMAPVPPGPRMA | 2609 | 186 | Q8N693 |
TCERG1 | HGNC:15630 | MMRGPPPPPRPPFGR | 2602 | 409 | O14776 |
ABR | HGNC:81 | LLLLNSPTIPFRIHN | 2598 | 289 | Q12979 |
EP400 | HGNC:11958 | AQPPPPQPQPPPPPQ | 2595 | 265 | Q96L91 |
MAPK14 | HGNC:6876 | IMRLTGTPPAYLINR | 2590 | 377 | Q16539 |
CSMD2 | HGNC:19290 | LMCKPPPLIPNGKVV | 2582 | 409 | Q7Z408 |
RYBP | HGNC:10480 | MGDKKSPTRPKRQAK | 2582 | 218 | Q8N488 |
FMNL3 | HGNC:23698 | FLRTAAPPAPLRTLL | 2561 | 277 | Q8IVF7 |
MAP1A | HGNC:6835 | RPLPPAPLSPAPGPP | 2544 | 333 | P78559 |
MEF2A | HGNC:6993 | RNHKIAPGLPPQNFS | 2539 | 284 | Q02078 |
TP53BP2 | HGNC:12000 | EYPPYPPPPYPSGEP | 2529 | 342 | Q13625 |
ALS2CR4 | HGNC:14432 | RPPRALPPVPSQDDI | 2528 | 246 | Q96Q45 |
MAPK1 | HGNC:6871 | HSANVLHRDLKPSNL | 2514 | 576 | P28482 |
CPXCR1 | HGNC:2332 | ITFRRPSRVHYYRPL | 2509 | 633 | Q8N123 |
TOX3 | HGNC:11972 | KKKKKDPNEPQKPVS | 2452 | 211 | O15405 |
INADL | HGNC:28881 | APPPMKLPPPYKALT | 2401 | 603 | Q8NI35 |
USP32 | HGNC:19143 | MGNVPSPNAPLKRVL | 2389 | 494 | Q8NFA0 |
GTF3C1 | HGNC:4664 | SWMRYIPPIPVHRDF | 2377 | 643 | Q12789 |
COL27A1 | HGNC:22986 | STPRTAPAVPTPGSA | 2331 | 225 | Q8IZC6 |
CC2D1A | HGNC:30237 | CLPPPPDQLPPDPPS | 2301 | 574 | Q6P1N0 |
ABHD5 | HGNC:21396 | RIGKMHPDIPVSVIF | 2297 | 312 | Q8WTS1 |
OBSCN | HGNC:15719 | DPSQPPPPPLQHYLE | 2288 | 463 | Q5VST9 |
YTHDF1 | HGNC:15867 | VMGGGLPPPPIKHNM | 2285 | 370 | Q9BYJ9 |
CHRM1 | HGNC:1950 | RRWRKIPKRPGSVHR | 4551 | 788 | P11229 |
EZH2 | HGNC:3527 | ERIKTPPKRPGGRRR | 2276 | 308 | Q15910 |
DNAH7 | HGNC:18661 | KKLKEAPPIPKDVMF | 2271 | 443 | Q8WXX0 |
PMEPA1 | HGNC:14107 | FEMRKKPPPEENGDY | 2269 | 645 | Q969W9 |
RBM26 | HGNC:20327 | VVEGPPPPGLPPPPP | 2266 | 256 | Q5T8P6 |
LRRTM4 | HGNC:19411 | ERSHLVPQTPQKPLI | 2265 | 190 | Q86VH4 |
GTF3C1 | HGNC:4664 | SWMRYIPPIPVHRDF | 2261 | 452 | Q12789 |
SMARCC1 | HGNC:11104 | MYPPPPQQQPPPPPP | 2260 | 293 | Q92922 |
TTLL11 | HGNC:18113 | VLQRPPPTLPPSKPK | 2257 | 234 | Q8NHH1 |
SRRM2 | HGNC:16639 | PGMKDIPRTPFRGRS | 2253 | 407 | O60382 |
MED24 | HGNC:22963 | YWNLLPPKRPIKEVL | 2250 | 706 | O75448 |
FRAS1 | HGNC:19185 | VMYRPPPAAPHLQEL | 2244 | 122 | Q86XX4 |
CDK15 | HGNC:14434 | HHQHVLHRDLKPQNL | 2243 | 204 | Q96Q40 |
REPIN1 | HGNC:17922 | HLQRCHPPAPAARPF | 2235 | 188 | Q9UMP5 |
ADAM20 | HGNC:199 | SSGLCIQPPPYPGNI | 2231 | 175 | O43506 |
PMPCA | HGNC:18667 | CSRLRFGPPAYRRFS | 2219 | 189 | Q10713 |
CASP10 | HGNC:1500 | AISAQTPRPPMRRWS | 2200 | 174 | Q92851 |
CDH23 | HGNC:13733 | GEIATRPAPPDRERQ | 2189 | 201 | Q9H251 |
AASS | HGNC:17366 | AWERRAPLAPKHIKG | 2177 | 189 | A4D0W4 |
ROD1 | HGNC:10253 | FSNSPLHRFKKPGSK | 2176 | 302 | O95758 |
SRGAP1 | HGNC:17382 | YMTTRPPNVPPKPQK | 2174 | 114 | O43295 |
PAX6 | HGNC:8620 | FEPRGIPRPPARASM | 2174 | 198 | P26367 |
ZNF622 | HGNC:30958 | MSPKKAPPAPAKEAR | 2171 | 117 | Q969S3 |
NFRKB | HGNC:7802 | PARSPSPAVPLRVVP | 2165 | 401 | Q6P4R8 |
CELSR1 | HGNC:1850 | SPSPSPPLPPNLPEA | 2132 | 142 | Q9NYQ6 |
AFARP1 | MGRRSHPRLPGARPH | 2120 | 317 | Q8NHP2 | |
SOX7 | HGNC:18196 | GHPRRIPHLPGHPYS | 2100 | 216 | Q9BT81 |
HNRNPK | HGNC:5044 | SPRRGPPPPPPGRGG | 2093 | 239 | P61978 |
TP53BP2 | HGNC:12000 | NVAKVPPPVPTKPKQ | 2091 | 177 | Q13625 |
BTN2A3 | HGNC:13229 | HRELVVPQLPARKKV | 2086 | 190 | Q96KV6 |
ASAP1 | HGNC:2720 | TLSKKRPPPPPPGHK | 2081 | 182 | Q9ULH1 |
ATN1 | HGNC:3033 | WSQGPPPPPPYGRLL | 2077 | 201 | P54259 |
C20orf26 | HGNC:15872 | ALHYLVPVRPRRQIV | 2070 | 140 | Q8NHU2 |
PCDHGA7 | HGNC:8705 | SFRKITPKLPKMFHL | 2054 | 113 | Q9Y5G6 |
ZSWIM4 | HGNC:25704 | EPPKEAPPRPWPRPG | 2051 | 145 | Q9HA55 |
FOXQ1 | HGNC:20951 | PPAPAAPASPRMRSP | 2032 | 176 | Q9C009 |
PTBP1 | HGNC:9583 | YGNSPLHRFKKPGSK | 2017 | 150 | P26599 |
GALNT10 | HGNC:19873 | MYYKRIPIPPELQKA | 2011 | 167 | Q86SR1 |
KERA | HGNC:6309 | RGLKEIPAIPSRIWY | 1987 | 107 | O60938 |
A4GALT | HGNC:18149 | PQPGREPRLPRRHHP | 1984 | 191 | Q9NPC4 |
OLFML3 | HGNC:24956 | YFARRPPGRPGGGGE | 1972 | 121 | Q9NRN5 |
ABCG5 | HGNC:13886 | KHLKTLPMVPFKTKD | 1970 | 201 | Q96QZ2 |
SH3KBP1 | HGNC:13867 | LQKPSVPAIPPKKPR | 1969 | 203 | Q96B97 |
PRG4 | HGNC:9364 | TKKKPTPKPPVVDEA | 1954 | 129 | Q92954 |
KIF1A | HGNC:888 | CKDVLSPLRPSRRHF | 1876 | 101 | Q12756 |
NEUROG2 | HGNC:13805 | PQPPPPPQPPATLQA | 1870 | 199 | Q9H2A3 |
NFRKB | HGNC:7802 | PARSPSPAVPLRVVP | 1866 | 172 | Q6P4R8 |
MN1 | HGNC:7180 | PQQPPQQQPPPPPGL | 1856 | 120 | Q10571 |
CTAGE1 | HGNC:24346 | FIRRGPPFPPPPPGT | 1830 | 173 | Q96RT6 |
CYP24A1 | HGNC:2602 | ESMRLTPSVPFTTRT | 1816 | 301 | Q07973 |
CDRT15 | HGNC:14395 | RLGRRVPAAPPALRR | 1813 | 149 | Q96T59 |
RTKN2 | HGNC:19364 | GKKRQAPLPPSDKLP | 1798 | 319 | Q8IZC4 |
UST | HGNC:17223 | SLLKLRPQPPLHPGA | 1792 | 207 | Q9Y2C2 |
DOK1 | HGNC:2990 | DYAVPPPRSTKPLLA | 1759 | 189 | Q99704 |
SNW1 | HGNC:16696 | LVSSRREPPPYGYRK | 1734 | 101 | Q13573 |
TRIM46 | HGNC:19019 | RAVRSVPGLPLLLAA | 1697 | 232 | Q7Z4K8 |
RIMS2 | HGNC:17283 | RRGRQLPQLPPKGTL | 1688 | 194 | Q9UQ26 |
SGK223 | RAGSLPPPPRLPPRP | 1654 | 120 | Q86YV5 | |
C1S | HGNC:1247 | LKAARLPVAPLRKCK | 1633 | 144 | P09871 |
JAK1 | HGNC:6190 | YESRCRPVTPSCKEL | 1573 | 165 | P23458 |
DOC2B | HGNC:2986 | PRAAAPPDAPARPAV | 1567 | 172 | Q14184 |
BMP8A | HGNC:21650 | LPGRPRPRAPPAASR | 1521 | 219 | Q7Z5Y6 |
PDE4A | HGNC:8780 | LPEPLAPRAPRRPRS | 1478 | 206 | P27815 |
MYRIP | HGNC:19156 | QQRRKLPAPPVKAEK | 1423 | 178 | Q8NFW9 |
NKX2-1 | HGNC:11825 | KNMAPLPSAPRRKRR | 1412 | 356 | P43699 |
NOTCH4 | HGNC:7884 | CLPSPKPGFPPRCAC | 1401 | 105 | Q99466 |
DNMT1 | HGNC:2976 | ARMRHIPLAPGSDWR | 1399 | 206 | P26358 |
SCYL2 | HGNC:19286 | GGGRWRPNAPRGRWP | 1392 | 319 | Q6P3W7 |
CDC27 | HGNC:1728 | LKMKFPPKIPNRKTK | 1390 | 105 | P30260 |
MYPN | HGNC:23246 | NGQPVLPDAPHKMLV | 1244 | 119 | Q86TC9 |
TTN | HGNC:12403 | KPRPPPPPPAPPKED | 1216 | 145 | Q8WZ42 |
CPSF7 | HGNC:30098 | YQHLMPPPPRLPPHL | 1200 | 216 | Q8N684 |
TRAF3IP2 | HGNC:1343 | QEMMPRPRPRPGPHR | 1188 | 97 | O43734 |
PHACTR1 | HGNC:20990 | LPVKLSPPLPPKKVM | 1154 | 119 | Q9C0D0 |
NLRP12 | HGNC:22938 | HSRLAALRVTKPYLD | 1139 | 105 | P59046 |
GPR63 | HGNC:13302 | KSFKFLPQLPGHTKR | 1124 | 156 | Q9BZJ6 |
ESX1 | HGNC:14865 | PVLPVPPMPPRPPMV | 1089 | 177 | A6ZIS2 |
PLEKHH3 | HGNC:26105 | DPPRPTPRPPPSAAL | 1081 | 194 | Q7Z736 |
RASGRP1 | HGNC:9878 | RNHRAPPLTPSKPPV | 1074 | 173 | O95267 |
TACC2 | HGNC:11523 | TTPVKAPPAPPPPPP | 1054 | 129 | O95359 |
PRDM14 | HGNC:14001 | SAAPAMPPFPFRMAP | 1023 | 187 | Q9GZV8 |
EIF4G2 | HGNC:3297 | KTSKKPPPSKEELLK | 1019 | 170 | P78344 |