G2Cdb::Allele report

Mutation type

Altered genes (1)

Gene Symbol Species Description
G00002162 FUS Homo sapiens fused in sarcoma

Diseases (1)

Disease Description Nervous effect
D00000005 Low grade fibromyxoid sarcoma N

Literature (1)

Pubmed - human_disease

  • Low-grade fibromyxoid sarcoma arising in the big toe.

    Kusumi T, Nishikawa S, Tanaka M, Ogawa T, Jin H, Sato F, Toh S, Hasegawa T and Kijima H

    Department of Pathology, Hirosaki University School of Medicine, Hirosaki, Japan. kusumito@cc.hirosaki-u.ac.jp

    Low-grade fibromyxoid sarcoma (LGFMS) is a rare tumor. Reported herein is a case of LGFMS arising in the big toe. The patient was a 58-year-old man who underwent excision of the tumor. The tumor was well-demarcated. Histologically, there were proliferating spindle-shaped tumor cells arranged in a whorled growth pattern, and the stroma showed hyalinized collagen bundles and a myxoid matrix. Nuclear mitotic figures were conspicuous in part. A large rosette-like structure with hyalinized stroma was found, which is characteristic of LGFMS. The differential diagnosis included tumor occurrence in adults; tending to arise in distal extremities; and having bland fibromyxoid histological features, such as fibroma of tendon sheath, low-grade myxofibrosarcoma and acral myxoinflammatory fibroblastic sarcoma. It was not possible to detect the FUS/CREB3L2 and FUS/CREB3L1 fusion genes from the formalin-fixed and paraffin-embedded tissue, although the histological features of the present case were typical of LGFMS. LGFMS may become more common with time, and unique cases may accumulate.

    Pathology international 2005;55;12;802-6

© G2C 2014. The Genes to Cognition Programme received funding from The Wellcome Trust and the EU FP7 Framework Programmes:
EUROSPIN (FP7-HEALTH-241498), SynSys (FP7-HEALTH-242167) and GENCODYS (FP7-HEALTH-241995).

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